NSC55655

• 常用名: NSC55655
• 英文名: 2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]
• CAS号: 36140-65-5
• 分子量: 250.23
• 密度: 1.595g/cm3
• 沸点: N/A
• 分子式: C₁₀H₆N₂O₄S
• 熔点: N/A
• 闪点: N/A

NSC55655用途

5-[(2-硝基苯基)亚甲基]-2,4-噻唑烷二酮(化合物4)具有抗菌、抗糖尿病和抗氧化活性。5-[(2-硝基苯基)亚甲基]-2,4-噻唑烷二酮对枯草芽孢杆菌、金黄色葡萄球菌、肺炎链球菌、大肠杆菌和斑疹伤寒杆菌的MIC为4.5-9.9μΜ/mL,对黑曲霉和白色念珠菌的MIC均为4.99μΜ/mL[1]。

NSC55655名称

• 中文名: NSC55655
• 英文名: 5-[(2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione

NSC55655生物活性

• 描述: 5-[(2-硝基苯基)亚甲基]-2,4-噻唑烷二酮(化合物4)具有抗菌、抗糖尿病和抗氧化活性。5-[(2-硝基苯基)亚甲基]-2,4-噻唑烷二酮对枯草芽孢杆菌、金黄色葡萄球菌、肺炎链球菌、大肠杆菌和斑疹伤寒杆菌的MIC为4.5-9.9μΜ/mL,对黑曲霉和白色念珠菌的MIC均为4.99μΜ/mL[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Elkamhawy A, et al. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. Eur J Med Chem. 2020 Feb 15;188:111955.

NSC55655物理化学性质

• 密度: 1.595g/cm3
• 分子式: C₁₀H₆N₂O₄S
• 分子量: 250.23
• 精确质量: 250.00500
• PSA: 117.29000
• LogP: 2.77070
• InChIKey: AOOOVMMYAYKAGI-VMPITWQZSA-N
• SMILES: O=C1NC(=O)C(=Cc2ccccc2[N+](=O)[O-])S1
• 外观性状: 黄色固体
• 折射率: 1.732
• 储存条件: -20℃

NSC55655安全信息

• 海关编码: 2934999090

NSC55655海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

NSC55655靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Confirmatory qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 ... 来源：NCGC External Id：epac1-activator-f1f2f3f4

实验名称：Confirmatory qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor... 来源：NCGC External Id：epac1-inhibitor-f1f2f3f4

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NSC55655英文别名

• 5-(2-nitro-benzylidene)-thiazolidine-2,4-dione
• 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione
• 5-(2-Nitro-benzyliden)-thiazolidin-2,4-dion