4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚

• 常用名: 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚
• 英文名: YL-109
• CAS号: 36341-25-0
• 分子量: 257.30800
• 密度: 1.327g/cm3
• 沸点: 446.448ºC at 760 mmHg
• 分子式: C₁₄H₁₁NO₂S
• 熔点: N/A
• 闪点: 223.804ºC

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚用途

YL-109是新型抗癌化合物,能抑制乳腺癌细胞的生长和扩增,抑制MCF-7细胞株的IC50值为85.7nM,AhR信号转导激动剂。

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚名称

• 中文名: YL-109
• 英文名: 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚生物活性

• 描述: YL-109是新型抗癌化合物,能抑制乳腺癌细胞的生长和扩增,抑制MCF-7细胞株的IC50值为85.7nM,AhR信号转导激动剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Hiyoshi H, et al. 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP. Sci Rep. 2014 Nov 18;4:7095.

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚物理化学性质

• 密度: 1.327g/cm3
• 沸点: 446.448ºC at 760 mmHg
• 分子式: C₁₄H₁₁NO₂S
• 分子量: 257.30800
• 闪点: 223.804ºC
• 精确质量: 257.05100
• PSA: 70.59000
• LogP: 3.67750
• InChIKey: KRVBOHJNAFQFPW-UHFFFAOYSA-N
• SMILES: COc1cc(-c2nc3ccccc3s2)ccc1O
• 外观性状: 固体
• 折射率: 1.685
• 储存条件: 2-8°C， 密闭， 干燥

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2934200090

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚海关

• 海关编码: 2934200090
• 中文概述: 2934200090. 其他含一个苯并噻唑环系的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚英文别名

• 2-(4-hydroxy-3-methoxyphenyl)benzo[d]thiazole
• 2-(3-methoxy-4-hydroxyphenyl)benzothiazole
• 4-(benzo[d]thiazol-2-yl)-2-methoxyphenol
• 4-(1,3-benzothiazol-2-yl)-2-methoxyphenol
• Phenol,4-(2-benzothiazolyl)-2-methoxy
• 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
• 4-benzothiazol-2-yl-2-methoxyphenol
• YL-109