EB-47

• 常用名: EB-47
• 英文名: PARP Inhibitor IX, EB-47
• CAS号: 366454-36-6
• 分子量: 537.52800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₇N₉O₆
• 熔点: N/A
• 闪点: N/A

EB-47用途

EB-47 是一种有效的 PARP-1/ARTD-1 选择性抑制剂,IC50 值为 45 nM,对 ARTD5 的IC50 值为 410 nM,表现出温和的药效。EB-47 模拟底物 NAD+,从烟酰胺延伸至腺苷亚区结合。

EB-47名称

• 英文名: 2-[4-[(2R,3R,4S,5S)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl]-N-(1-oxo-2,3-dihydroisoindol-4-yl)acetamide

EB-47生物活性

• 描述: EB-47 是一种有效的 PARP-1/ARTD-1 选择性抑制剂,IC50 值为 45 nM,对 ARTD5 的IC50 值为 410 nM,表现出温和的药效。EB-47 模拟底物 NAD+,从烟酰胺延伸至腺苷亚区结合。
• 相关类别:
  信号通路 >> 表观遗传学 >> PARP
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 靶点实验:

  ARTD1/PARP1:45 nM (IC50)

• 体外研究: EB-47对CdPARP的抑制率超过50%,IC50值分别为0.86和1.0μM时,EB-47对CdPARP和HsPARP具有抑制作用[1]。
• 体内研究: EB-47(2μM；5d)可减少第5天胚胎着床点和囊胚数。PARP1参与胚胎着床过程[3]。
• 参考文献:

  [1]. Haikarainen T, et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors.ACS Med Chem Lett. 2013 Nov 20;5(1):18-22.

  [2]. García-Saura AG, et al. Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model. Sci Rep. 2018 May 23;8(1):8056.

  [3]. Joshi A, et al.PARP1 during embryo implantation and its upregulation by oestradiol in mice.Reproduction. 2014 Jun;147(6):765-80.

  [4]. Jagtap PG, et al. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).Bioorg Med Chem Lett. 2004 Jan 5;14(1):81-5.

EB-47物理化学性质

• 分子式: C₂₄H₂₇N₉O₆
• 分子量: 537.52800
• 精确质量: 537.20800
• PSA: 208.04000
• InChIKey: DDFLFKTXUWPNMV-LFALDJFMSA-N
• SMILES: Nc1ncnc2c1ncn2C1OC(C(=O)N2CCN(CC(=O)Nc3cccc4c3CNC4=O)CC2)C(O)C1O

EB-47靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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EB-47英文别名

• 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-|A-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide Dihydrochloride
• 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride
• EB 47