ROS kinases-IN-1

• 常用名: ROS kinases-IN-1
• 英文名: ROS kinases-IN-1
• CAS号: 370096-57-4
• 分子量: 328.373
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₆N₄O
• 熔点: N/A
• 闪点: N/A

ROS kinases-IN-1用途

ROS激酶IN-1(第98页)是一种ROS酪氨酸激酶抑制剂,IC50值为1.22μM。ROS激酶IN-1显示出抗肿瘤活性[1]。

ROS kinases-IN-1名称

• 英文名: WAY-602746

ROS kinases-IN-1生物活性

• 描述: ROS激酶IN-1(第98页)是一种ROS酪氨酸激酶抑制剂,IC50值为1.22μM。ROS激酶IN-1显示出抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
• 靶点实验:

  IC50: 1.22 μM (ROS kinase)[1]

• 体外研究: ROS激酶IN-1(1-100μM；1 d)抑制宫颈癌细胞和胶质母细胞瘤细胞的生长[1]。细胞活力测定[1]细胞系：HeLa、U138、U87、LN18和U118细胞浓度：1、10和100μM孵育时间：一天结果：HeLa,U138,U87,LN18和U118细胞的EC50分别为20、8、8、12和7μM。
• 参考文献:

  [1]. Dorre A. GRUENEBERG, et al. Novel methods, compounds, and compositions for inhibition of ros. WO2014141129A2.

ROS kinases-IN-1物理化学性质

• 分子式: C₂₀H₁₆N₄O
• 分子量: 328.373
• InChIKey: DGSFFYVACCJJGR-PDGQHHTCSA-N
• SMILES: CC1=NNC(=O)C1=Cc1cn(-c2ccccc2)nc1-c1ccccc1
• 储存条件: -80℃储存

ROS kinases-IN-1靶点实验

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