N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺

• 常用名: N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺
• 英文名: LY450108
• CAS号: 376594-67-1
• 分子量: 396.451
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₉H₂₂F₂N₂O₃S
• 熔点: N/A
• 闪点: N/A

用途

LY450108是AMPA受体增强剂。

名称

• 中文名: N-[4-[(1R)-1-甲基-2-[[异丙基磺酰基]氨基]乙基]苯基]-3,5-二氟苯基甲酰胺
• 英文名: 3,5-difluoro-N-[4-[(2R)-1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide

生物活性

• 描述: LY450108是AMPA受体增强剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

  [2]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.

  [3]. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.

  [4]. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₉H₂₂F₂N₂O₃S
• 分子量: 396.451
• 精确质量: 396.131927
• PSA: 83.65000
• LogP: 3.41
• InChIKey: ACOXQYLJOQAHST-ZDUSSCGKSA-N
• SMILES: CC(CNS(=O)(=O)C(C)C)c1ccc(NC(=O)c2cc(F)cc(F)c2)cc1
• 折射率: 1.568
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Activation of human GluR2 flip isoform expressed in HEK293 cells assessed as increase... 来源：ChEMBL 靶标：Glutamate receptor 2 External Id：CHEMBL1217484

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Activation of human GluR2 flip isoform expressed in HEK293 cells assessed as increase... 来源：ChEMBL 靶标：Glutamate receptor 2 External Id：CHEMBL1217483

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

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英文别名

• (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
• QCR-13
• CS-1090
• 3,5-Difluoro-N-(4-{(2R)-1-[(isopropylsulfonyl)amino]-2-propanyl}phenyl)benzamide
• LY450108