岩大戟内酯B

• 常用名: 岩大戟内酯B
• 英文名: Jolkinolide B
• CAS号: 37905-08-1
• 分子量: 330.418
• 密度: 1.3±0.1 g/cm3
• 沸点: 497.1±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₄
• 熔点: N/A
• 闪点: 219.8±28.8 °C

岩大戟内酯B用途

用于含量测定/鉴定/药理实验等。

岩大戟内酯B名称

• 中文名: 岩大戟内酯B
• 英文名: 1,4-dibutyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide,nitrous acid

岩大戟内酯B生物活性

• 描述: Jolkinolide B 是一种从大戟根中分离得到的具有生物活性的二萜类化合物,目前已知它能诱导癌细胞凋亡 (apoptosis)。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 靶点实验:

  IC50: apoptosis[1]

• 参考文献:

  [1]. Wang, J., Zhou, Y., Bai, X. et al. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells 32, 451–457 (2011).

岩大戟内酯B物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 497.1±45.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆O₄
• 分子量: 330.418
• 闪点: 219.8±28.8 °C
• 精确质量: 330.183105
• PSA: 51.36000
• LogP: 3.24
• InChIKey: SOVOCMGDFRGRKF-MCDHERAVSA-N
• SMILES: CC1=C2C3OC34CCC3C(C)(C)CCCC3(C)C4C3OC23OC1=O
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 2-8℃

岩大戟内酯B靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3751506

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3751505

实验名称：Antimycobacterial activity against Mycobacterium smegmatis after 24 hrs by microplate... 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL4119106

实验名称：Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4712311

实验名称：Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hr... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3782899

实验名称：Cytotoxicity against human HCT8 cells by MTT assay 来源：ChEMBL 靶标：HCT-8 External Id：CHEMBL933776

实验名称：Cytotoxicity against human BGC 823 cells by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL933775

实验名称：Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assa... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3872005

实验名称：Antitumor activity against mouse B16-F10 cells allografted in C57BL/6 mouse assessed ... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL4712332

实验名称：Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3872006

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岩大戟内酯B英文别名

• (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-4,4,8,11c-Tetramethyl-1,2,3,4,4a,5,6,11a,11b,11c-decahydrobisoxireno[3,4:1,10a]phenanthro[3,2-b]furan-9(7aH)-one
• 2-Piperazinecarboxamide,1,4-dibutyl-N-(2,6-dimethylphenyl)-,dinitrate
• 1,4-dibutyl-n-(2,6-dimethylphenyl)piperazine-2-carboxamide ntrite(1:2)
• jokiolide B
• jolkinolide B
• 2-Piperazinecarboxanilide,1,4-dibutyl-2',6'-dimethyl-,dinitrate
• 1,4-dibutyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide