CAY10760

• 常用名: CAY10760
• 英文名: CAY10760
• CAS号: 391889-85-3
• 分子量: 485.961
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₈H₂₄ClN₃O₃
• 熔点: N/A
• 闪点: N/A

CAY10760用途

同源重组-IN-1是一种新的RAD51-BRCA2蛋白-蛋白相互作用抑制剂(EC50=19μM)。同源重组-IN-1可以干扰同源重组[1]。

CAY10760名称

• 英文名: CAY10760

CAY10760生物活性

• 描述: 同源重组-IN-1是一种新的RAD51-BRCA2蛋白-蛋白相互作用抑制剂(EC50=19μM)。同源重组-IN-1可以干扰同源重组[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> RAD51
• 体外研究: 同源重组-IN-1(10-40μM；5 h)以剂量依赖性方式减少细胞同源重组[1]。Western Blot分析[1]细胞系：BxPC3细胞浓度：10-40μM培养时间：5小时结果：导致同源重组抑制,EC50值为18.4μM。

CAY10760物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₈H₂₄ClN₃O₃
• 分子量: 485.961
• 精确质量: 485.150604
• LogP: 4.39
• InChIKey: LAVOKBSCOSIGER-UHFFFAOYSA-N
• SMILES: CCC(=O)N1N=C(c2c(-c3ccccc3)c3cc(Cl)ccc3[nH]c2=O)CC1c1ccc(OC)cc1
• 折射率: 1.660

CAY10760靶点实验

查看更多实验

实验名称：Inhibition of biotinylated BRC4 peptide binding to His-tagged human RAD51 expressed i... 来源：ChEMBL 靶标：DNA repair protein RAD51 homolog 1 External Id：CHEMBL4404468

实验名称：Synergistic antiproliferative activity against human BxPC3 cells at 20 uM after 72 hr... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404485

实验名称：Cytotoxicity against human HK2 cells at 20 uM after 72 hrs in presence of 10 uM olapa... 来源：ChEMBL 靶标：HK-2 External Id：CHEMBL4404486

实验名称：Synergistic antiproliferative activity against BRCA2 defective human Capan1 cells at ... 来源：ChEMBL 靶标：CAPAN-1 External Id：CHEMBL4404487

实验名称：Antiproliferative activity against human BxPC3 cells at 15 uM after 72 hrs in presenc... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404491

实验名称：Inhibition of RAD51 in BRCA2 defective human Capan1 cells assessed as increase in gam... 来源：ChEMBL 靶标：DNA repair protein RAD51 homolog 1 External Id：CHEMBL4404478

实验名称：Induction of DNA damage in human BxPC3 cells assessed as micronuclei formation at 20 ... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404479

实验名称：Induction of DNA damage in human BxPC3 cells assessed as micronuclei formation at 20 ... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404480

实验名称：Antiproliferative activity against human BxPC3 cells assessed as increase in cell dea... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404481

实验名称：Antiproliferative activity against human BxPC3 cells assessed as increase in cell dea... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL4404482

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CAY10760英文别名

• CAY10760
• 6-Chloro-3-[5-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone