MitoBloCK-10

• 常用名: MitoBloCK-10
• 英文名: MitoBloCK-10
• CAS号: 394694-98-5
• 分子量: 293.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₈FN₃O₃S
• 熔点: N/A
• 闪点: N/A

MitoBloCK-10用途

MitoBloCK-10(MB-10)是通过靶向Tim44进入线粒体的蛋白质的潜在衰减剂,抑制使用TIM23输入途径的底物的输入；靶向Tim44和Tim44的C末端结构域的α4螺旋的突变赋予抵抗力。对MitoBloCK-10(MB-10)；MitoBloCK-10(MB-10)抑制Tim44与前体和Hsp70的结合,但不抑制PAM复合物的其他成分；在MTT测定中抑制Hela细胞活力,IC50为17.2 uM,损害心脏发育并诱导斑马鱼细胞凋亡。

MitoBloCK-10名称

• 中文名: 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼
• 英文名: 3-Fluoro-N'-[(E)-(5-nitro-2-thienyl)methylene]benzohydrazide

MitoBloCK-10生物活性

• 描述: MitoBloCK-10(MB-10)是通过靶向Tim44进入线粒体的蛋白质的潜在衰减剂,抑制使用TIM23输入途径的底物的输入；靶向Tim44和Tim44的C末端结构域的α4螺旋的突变赋予抵抗力。对MitoBloCK-10(MB-10)；MitoBloCK-10(MB-10)抑制Tim44与前体和Hsp70的结合,但不抑制PAM复合物的其他成分；在MTT测定中抑制Hela细胞活力,IC50为17.2 uM,损害心脏发育并诱导斑马鱼细胞凋亡。
• 参考文献: References 1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA. 2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442. View Related Products by Target Other Targets

MitoBloCK-10物理化学性质

• 分子式: C₁₂H₈FN₃O₃S
• 分子量: 293.27
• InChIKey: QDYQZMWFIYLMNX-UHFFFAOYSA-N
• SMILES: O=C(NN=Cc1ccc([N+](=O)[O-])s1)c1cccc(F)c1
• 储存条件: 2-8°C

MitoBloCK-10安全信息

• 危害码 (欧洲): Xi

MitoBloCK-10靶点实验

查看更多实验

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

共3条，当前第1页，共1页

1

MitoBloCK-10英文别名

• 3-Fluoro-N'-[(E)-(5-nitro-2-thienyl)methylene]benzohydrazide
• Benzoic acid, 3-fluoro-, 2-[(1E)-(5-nitro-2-thienyl)methylene]hydrazide