MitoBloCK-10
Modify Date: 2024-03-06 11:22:48
MitoBloCK-10 structure
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Common Name | MitoBloCK-10 | ||
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| CAS Number | 394694-98-5 | Molecular Weight | 293.27 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H8FN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MitoBloCK-10MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway; targets Tim44 and mutations in the α4 helix of the C-terminal domain of Tim44 confer resistence to MitoBloCK-10 (MB-10); MitoBloCK-10 (MB-10) inhibits Tim44 binding to the precursor and to Hsp70, but not other component of the PAM complex; inhibits Hela cell viability with IC50 of 17.2 uM in MTT assays, impairs cardiac development and induces apoptosis in zebrafish. |
| Name | 3-Fluoro-N'-[(E)-(5-nitro-2-thienyl)methylene]benzohydrazide |
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| Synonym | More Synonyms |
| Description | MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway; targets Tim44 and mutations in the α4 helix of the C-terminal domain of Tim44 confer resistence to MitoBloCK-10 (MB-10); MitoBloCK-10 (MB-10) inhibits Tim44 binding to the precursor and to Hsp70, but not other component of the PAM complex; inhibits Hela cell viability with IC50 of 17.2 uM in MTT assays, impairs cardiac development and induces apoptosis in zebrafish. |
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| References | References 1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA. 2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442. View Related Products by Target Other Targets |
| Molecular Formula | C12H8FN3O3S |
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| Molecular Weight | 293.27 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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| 3-Fluoro-N'-[(E)-(5-nitro-2-thienyl)methylene]benzohydrazide |
| Benzoic acid, 3-fluoro-, 2-[(1E)-(5-nitro-2-thienyl)methylene]hydrazide |