Qc1

• 常用名: Qc1
• 英文名: Qc 1
• CAS号: 403718-45-6
• 分子量: 455.452
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₁₆F₃N₃O₂S
• 熔点: N/A
• 闪点: N/A

Qc1用途

Qc1是一种可逆的非竞争性苏氨酸脱氢酶(TDH)抑制剂。Qc1可用于代谢性疾病的研究[1][2]。

Qc1名称

• 英文名: N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide

Qc1生物活性

• 描述: Qc1是一种可逆的非竞争性苏氨酸脱氢酶(TDH)抑制剂。Qc1可用于代谢性疾病的研究[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  TDH[1]

• 体外研究: Qc1(10μM；2~24小时；ES细胞)表明,LC3总蛋白中有相当一部分是LC3-I(细胞质)形式。在TDH抑制16小时后,大多数LC3转化为LC3-II(脂质修饰)形式,表明自噬活性增加[2]。Qc1阻断四氢叶酸的充电。Qc1阻止苏氨酸脱氢酶将苏氨酸分解为乙酰辅酶A和甘氨酸[1][2]。
• 参考文献:

  [1]. Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193.

  [2]. Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833.

Qc1物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₃H₁₆F₃N₃O₂S
• 分子量: 455.452
• 精确质量: 455.091522
• PSA: 98.98000
• LogP: 4.34
• InChIKey: IFNVTSPDMUUAFY-UHFFFAOYSA-N
• SMILES: O=C(NCc1ccccc1)c1ccc2c(=O)n(-c3cccc(C(F)(F)F)c3)c(=S)[nH]c2c1
• 折射率: 1.682

Qc1安全信息

• 危险品运输编码: NONH for all modes of transport

Qc1靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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Qc1英文别名

• N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide