亚太因

• 常用名: 亚太因
• 英文名: Yatein
• CAS号: 40456-50-6
• 分子量: 400.422
• 密度: 1.3±0.1 g/cm3
• 沸点: 564.9±45.0 °C at 760 mmHg
• 分子式: C₂₂H₂₄O₇
• 熔点: N/A
• 闪点: 246.2±28.8 °C

亚太因用途

Yatein 是从 A. chilensis 中提取的木质素,具有抗增殖活性。Yatein 能通过阻断立早基因基因表达,抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。

亚太因名称

• 中文名: (-)-反式-3-(3,4-亚甲基二氧基苄基)-2-(3,4,5-三甲氧基苄基)丁内酯
• 英文名: (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one
• 中文别名: 亚太因

亚太因生物活性

• 描述: Yatein 是从 A. chilensis 中提取的木质素,具有抗增殖活性。Yatein 能通过阻断立早基因基因表达,抑制单纯疱疹病毒 1 型 (HSV-1) 的复制。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
• 参考文献:

  [1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85.

  [2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20.

亚太因物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 564.9±45.0 °C at 760 mmHg
• 分子式: C₂₂H₂₄O₇
• 分子量: 400.422
• 闪点: 246.2±28.8 °C
• 精确质量: 400.152191
• PSA: 72.45000
• LogP: 3.06
• InChIKey: GMLDZDDTZKXJLU-JKSUJKDBSA-N
• SMILES: COc1cc(CC2C(=O)OCC2Cc2ccc3c(c2)OCO3)cc(OC)c1OC
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.577

亚太因靶点实验

查看更多实验

实验名称：Retention time of the compound by ELSD chromatography 来源：ChEMBL 靶标：N/A External Id：CHEMBL3239071

实验名称：Inhibition of human liver microsome CYP2D6 in assessed as [14C]formaldehyde formation 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL970954

实验名称：Inhibition of human liver microsome CYP3A4 in assessed as [14C]formaldehyde formation 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL970953

实验名称：Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1000968

实验名称：Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1000967

实验名称：Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1000970

实验名称：Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1000969

实验名称：Toxicity in brine shrimp 来源：ChEMBL 靶标：Artemia External Id：CHEMBL998376

实验名称：Antimitotic activity in rat ASK cells assessed as reversal of astrocyte formation at ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL998378

实验名称：Cytotoxicity in mouse P388 cells 来源：ChEMBL 靶标：P388 External Id：CHEMBL998377

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亚太因英文别名

• Yatein
• (3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydro-2(3H)-furanone
• (3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one
• Deoxypodorhizone
• Dihydroanhydropodorhizol