TLR4-IN-C34

• 常用名: TLR4-IN-C34
• 英文名: TLR4-IN-C34
• CAS号: 40592-88-9
• 分子量: 389.398
• 密度: 1.2±0.1 g/cm3
• 沸点: 519.8±50.0 °C at 760 mmHg
• 分子式: C₁₇H₂₇NO₉
• 熔点: N/A
• 闪点: 268.2±30.1 °C

TLR4-IN-C34用途

TLR4-IN-C34 是具有口服活性的 TLR4 抑制剂,可改善内毒素血症和坏死性小肠结肠炎模型的全身炎症。

TLR4-IN-C34名称

• 英文名: Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside

TLR4-IN-C34生物活性

• 描述: TLR4-IN-C34 是具有口服活性的 TLR4 抑制剂,可改善内毒素血症和坏死性小肠结肠炎模型的全身炎症。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
• 体内研究: TLR4-IN-C34(C34,1 mg/kg,每日口服)可减轻NEC的严重程度,并显示肠粘膜的明显保存[1]。动物模型：7-8日龄小鼠诱导的实验性NEC[1]。用量：1 mg/kg。给药：每天早晨口服。结果：肠道炎症减轻。
• 参考文献:

  [1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.

  [2]. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

TLR4-IN-C34物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 519.8±50.0 °C at 760 mmHg
• 分子式: C₁₇H₂₇NO₉
• 分子量: 389.398
• 闪点: 268.2±30.1 °C
• 精确质量: 389.168579
• LogP: 0.83
• InChIKey: KMIQMFHPUJUDMC-HHARLNAUSA-N
• SMILES: CC(=O)NC1C(OC(C)C)OC(COC(C)=O)C(OC(C)=O)C1OC(C)=O
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.484
• 储存条件: -20°C，密闭，干燥

TLR4-IN-C34安全信息

• 危险品运输编码: NONH for all modes of transport

TLR4-IN-C34靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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TLR4-IN-C34英文别名

• α-D-Glucopyranoside, 1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate
• Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
• MFCD28053519
• TLR4-IN-C34