TLR4-IN-C34

Modify Date: 2024-01-11 19:55:02

TLR4-IN-C34 structure	Common Name	TLR4-IN-C34
	CAS Number	40592-88-9	Molecular Weight	389.398
	Density	1.2±0.1 g/cm3	Boiling Point	519.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₇NO₉	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	268.2±30.1 °C

Use of TLR4-IN-C34

TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].

Name	Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
Synonym	More Synonyms

Description	TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
In Vivo	TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa[1]. Animal Model: Experimental NEC induced in 7-8 day old mice[1]. Dosage: 1 mg/kg. Administration: Orally every morning. Result: Attenuated intestinal inflammation.
References	[1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. [2]. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

Density	1.2±0.1 g/cm3
Boiling Point	519.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₇NO₉
Molecular Weight	389.398
Flash Point	268.2±30.1 °C
Exact Mass	389.168579
LogP	0.83
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.484

RIDADR	NONH for all modes of transport

α-D-Glucopyranoside, 1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate

Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside

MFCD28053519

TLR4-IN-C34

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TLR4-IN-C34
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: TLR4-IN-C34
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: TLR4-IN-C34
Price: $700.0/100mg $1100.0/250mg $1900.0/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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