2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

• 常用名: 2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol
• 英文名: 2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol
• CAS号: 40725-89-1
• 分子量: 250.25
• 密度: 1.75g/cm3
• 沸点: 601.3ºC at 760 mmHg
• 分子式: C₁₁H₁₄N₄O₃
• 熔点: N/A
• 闪点: 317.5ºC

用途

7-(3-脱氧-β-D-红-内呋喃基)-7H-吡咯并[2,3-D]嘧啶-4-胺是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 英文名: 2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolan-3-ol

生物活性

• 描述: 7-(3-脱氧-β-D-红-内呋喃基)-7H-吡咯并[2,3-D]嘧啶-4-胺是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 密度: 1.75g/cm3
• 沸点: 601.3ºC at 760 mmHg
• 分子式: C₁₁H₁₄N₄O₃
• 分子量: 250.25
• 闪点: 317.5ºC
• 精确质量: 250.10700
• PSA: 106.42000
• LogP: 0.23540
• InChIKey: GAKDEQRUZQIUER-UHFFFAOYSA-N
• SMILES: Nc1ncnc2c1ccn2C1OC(CO)CC1O
• 折射率: 1.797

毒性和生态

靶点实验

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英文别名

• Tubercidin-5'-phosphat
• tubercidin-5-monophosphate
• 3'-deoxytubercidin
• TUBERCIDIN-5'-O-MONOPHOSPHATE SODIUM SALT
• 7-deaza-[5']adenylic acid
• 7-CH-5'-AMP SODIUM SALT
• 7-DEAZAADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT
• 5'-deoxy-5'-(methylthio)tubercidin
• tubercidin 5'-phosphate