2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

Modify Date: 2024-01-06 17:46:55

2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol structure	Common Name	2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol
	CAS Number	40725-89-1	Molecular Weight	250.25
	Density	1.75g/cm3	Boiling Point	601.3ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₄N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	317.5ºC

Use of 2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolan-3-ol
Synonym	More Synonyms

Description	7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.75g/cm3
Boiling Point	601.3ºC at 760 mmHg
Molecular Formula	C₁₁H₁₄N₄O₃
Molecular Weight	250.25
Flash Point	317.5ºC
Exact Mass	250.10700
PSA	106.42000
LogP	0.23540
Index of Refraction	1.797

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8833100

CHEMICAL NAME :: 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

CAS REGISTRY NUMBER :: 40725-89-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H14-N4-O3

MOLECULAR WEIGHT :: 250.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 3200 ug/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,481,1987

Precursor 0
DownStream 1
CAS#:40627-30-3 7-Deaza-ddA

Tubercidin-5'-phosphat

tubercidin-5-monophosphate

3'-deoxytubercidin

TUBERCIDIN-5'-O-MONOPHOSPHATE SODIUM SALT

7-deaza-[5']adenylic acid

7-CH-5'-AMP SODIUM SALT

7-DEAZAADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT

5'-deoxy-5'-(methylthio)tubercidin

tubercidin 5'-phosphate

2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

Use of 2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Precursor & DownStream

Synonyms