3-葡萄糖醛酮

更新时间：2024-01-05 13:48:27

3-葡萄糖醛酮结构式	常用名	3-葡萄糖醛酮	英文名	D-3-Deoxyglucosone
	CAS号	4084-27-9	分子量	162.141
	密度	1.4±0.1 g/cm3	沸点	400.1±45.0 °C at 760 mmHg
	分子式	C₆H₁₀O₅	熔点	73-75ºC
	MSDS	中文版美版	闪点	209.9±25.2 °C

3-葡萄糖醛酮用途

3-Deoxyglucosone (3-Deoxy-D-glucosone) 是美拉德反应和多元醇途径的反应中间体 (intermediate)。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化终产物 (AGEs),例如咪唑啉酮,它是 3-DG 的最特异 AGE。3-Deoxyglucosone 可以与低葡萄糖协同作用以增强 GLP-1 分泌,可以作为糖尿病生物学检测的标志物。

中文名	3-葡萄糖醛酮
英文名	3-deoxyglucosone
英文别名	更多

描述	3-Deoxyglucosone (3-Deoxy-D-glucosone) 是美拉德反应和多元醇途径的反应中间体 (intermediate)。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化终产物 (AGEs),例如咪唑啉酮,它是 3-DG 的最特异 AGE。3-Deoxyglucosone 可以与低葡萄糖协同作用以增强 GLP-1 分泌,可以作为糖尿病生物学检测的标志物。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 代谢疾病
参考文献	[1]. Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646. [2]. Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):4-11. [3]. Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78. [4]. Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):23-36.

描述

相关类别

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

参考文献

[1]. Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646.

[2]. Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):4-11.

[3]. Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78.

[4]. Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):23-36.

密度	1.4±0.1 g/cm3
沸点	400.1±45.0 °C at 760 mmHg
熔点	73-75ºC
分子式	C₆H₁₀O₅
分子量	162.141
闪点	209.9±25.2 °C
精确质量	162.052826
PSA	94.83000
LogP	-2.38
外观性状	固体
蒸汽压	0.0±2.1 mmHg at 25°C
折射率	1.512
储存条件	室温

3-葡萄糖醛酮毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

3-Deoxyglucosone: a potential glycating agent accountable for structural alteration in H3 histone protein through generation of different AGEs.

PLoS ONE 10(2) , e0116804, (2015)

Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One of the consequences of the Maillard reaction is attributed to the pro...

Studies on the Formation of Maillard and Caramelization Products from Glucosamine Incubated at 37 °C.

J. Agric. Food Chem. 63 , 6249-61, (2015)

This experiment compared the in vitro degradation of glucosamine (GlcN), N-acetylglucosamine, and glucose in the presence of NH3 incubated at 37 °C in phosphate buffer from 0.5 to 12 days. The reactio...

GC-MS Method for the Quantitation of Carbohydrate Intermediates in Glycation Systems.

J. Agric. Food Chem. 63 , 5911-9, (2015)

Glycation is a ubiquitous nonenzymatic reaction of carbonyl compounds with amino groups of peptides and proteins, resulting in the formation of advanced glycation end-products (AGEs) and thereby affec...

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