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鸦胆亭

鸦胆亭用途

Bruceantin(NSC165563)可从痢鸦胆子中提取，对B16黑色素瘤，结肠癌38，L1210和白血病P388有抑制性。

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鸦胆亭名称

[ CAS 号 ]:
41451-75-6

[ 中文名 ]:
鸦胆亭

[ 英文名 ]:
Bruceantin

[中文别名 ]:

鸦胆停

[英文别名 ]:

鸦胆亭生物活性

[ 描述 ]:

Bruceantin(NSC165563)可从痢鸦胆子中提取,对B16黑色素瘤,结肠癌38,L1210和白血病P388有抑制性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 其他

[参考文献]

[1]. Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.

[2]. Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.

[相关活性小分子]

鸦胆亭物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
731.0±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₈H₃₆O₁₁

[ 分子量 ]:
548.579

[ 闪点 ]:
239.4±26.4 °C

[ 精确质量 ]:
548.225769

[ PSA ]:
165.89000

[ LogP ]:
2.96

[ 蒸汽压 ]:
0.0±5.4 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
-20°C

鸦胆亭毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EH8798000

CHEMICAL NAME :: Bruceantin

CAS REGISTRY NUMBER :: 41451-75-6

LAST UPDATED :: 198605

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C28-H36-O11

MOLECULAR WEIGHT :: 548.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7027 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2727 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3359 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1950 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 15 umol/L

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,883,1979

鸦胆亭

鸦胆亭用途

鸦胆亭名称

鸦胆亭生物活性

鸦胆亭物理化学性质

鸦胆亭毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

鸦胆亭合成路线

详细合成路线

鸦胆亭上下游产品

鸦胆亭上游产品

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