3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮

• 常用名: 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
• 英文名: RI-1
• CAS号: 415713-60-9
• 分子量: 361.608
• 密度: 1.6±0.1 g/cm3
• 沸点: 483.0±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₁Cl₃N₂O₃
• 熔点: N/A
• 闪点: 245.9±28.7 °C

用途

RI-1是RAD51抑制剂,IC50在5到30 μM之间。

名称

• 中文名: 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
• 英文名: 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione

生物活性

• 描述: RI-1是RAD51抑制剂,IC50在5到30 μM之间。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> RAD51
  研究领域 >> 癌症
• 参考文献:

  [1]. dke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 May 9.

物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 483.0±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₁Cl₃N₂O₃
• 分子量: 361.608
• 闪点: 245.9±28.7 °C
• 精确质量: 359.983521
• PSA: 49.85000
• LogP: 3.04
• InChIKey: MWSUIZKGNWELRF-UHFFFAOYSA-N
• SMILES: O=C1C(Cl)=C(N2CCOCC2)C(=O)N1c1ccc(Cl)c(Cl)c1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.669
• 储存条件: -20°C

安全信息

• 危险品运输编码: NONH for all modes of transport

靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5303714

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5303713

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Effect on stabilization of Escherichia coli BL21(DE3) expressing human N-terminal 6-h... 来源：ChEMBL 靶标：DNA repair protein RAD51 homolog 1 External Id：CHEMBL3825092

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

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英文别名

• 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
• S8077,RAD51 inhibitor 1
• 3-Chloro-1-(3,4-dichloro-phenyl)-4-morpholin-4-yl-pyrrole-2,5-dione
• 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
• RI-1