RI-1
Modify Date: 2024-01-16 17:24:21
RI-1 structure
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Common Name | RI-1 | ||
|---|---|---|---|---|
| CAS Number | 415713-60-9 | Molecular Weight | 361.608 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 483.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H11Cl3N2O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 245.9±28.7 °C | |
Use of RI-1RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo: |
| Name | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.IC50 Value: 5-30 μMTarget: RAD51in vitro: RI-1 sensitizes cells to DNA damage by directly and specifically disrupting HsRAD51 and inhibiting the ability of RAD51 to form filaments on ssDNA. In addition, RI-1 alone generates single-agent toxicity in all three cancer cell lines (HeLa, MCF-7 and U2OS) with LD50 values in the 20–40 μM range. RI-1 decreases the rejoining of γ-H2AX foci in G2 phase cells and results in a higher level of unrepaired DSBs 6 hours after irradiation. in vivo: |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 483.0±45.0 °C at 760 mmHg |
| Molecular Formula | C14H11Cl3N2O3 |
| Molecular Weight | 361.608 |
| Flash Point | 245.9±28.7 °C |
| Exact Mass | 359.983521 |
| PSA | 49.85000 |
| LogP | 3.04 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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RI-1 CAS#:415713-60-9 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 22 p. 6560 - 6564 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)- |
| 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione |
| S8077,RAD51 inhibitor 1 |
| 3-Chloro-1-(3,4-dichloro-phenyl)-4-morpholin-4-yl-pyrrole-2,5-dione |
| 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione |
| RI-1 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: RI-1
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: RI-1
- Price: ￥2056.0/25mg ￥1016.0/10mg ￥3896.0/50mg ￥586.0/5mg
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: RI-1
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: RI-1
- Price: $450.0/100mg $900.0/250mg $1800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥561.6/5mg
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