RUVBL1/2 ATPase-IN-1

• 常用名: RUVBL1/2 ATPase-IN-1
• 英文名: RUVBL1/2 ATPase-IN-1
• CAS号: 423128-55-6
• 分子量: 507.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₈F₃N₅O
• 熔点: N/A
• 闪点: N/A

RUVBL1/2 ATPase-IN-1用途

RUVBL1/2 ATP酶-IN-1(化合物18)是一种有效且选择性的RUVBL1/2 ATP酶抑制剂,IC50值分别为6.0和7.7μM。RUVBL1和RUVBL2是高度保守的AAA ATP酶(与各种细胞活动相关的ATP酶),与癌症的进展高度相关。RUVBL1/2 ATPase-IN-1在癌症疾病研究中具有潜在的应用前景[1]。

RUVBL1/2 ATPase-IN-1名称

• 英文名: RUVBL1/2 ATPase-IN-1

RUVBL1/2 ATPase-IN-1生物活性

• 描述: RUVBL1/2 ATP酶-IN-1(化合物18)是一种有效且选择性的RUVBL1/2 ATP酶抑制剂,IC50值分别为6.0和7.7μM。RUVBL1和RUVBL2是高度保守的AAA ATP酶(与各种细胞活动相关的ATP酶),与癌症的进展高度相关。RUVBL1/2 ATPase-IN-1在癌症疾病研究中具有潜在的应用前景[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.

RUVBL1/2 ATPase-IN-1物理化学性质

• 分子式: C₂₈H₂₈F₃N₅O
• 分子量: 507.55
• InChIKey: DWMRUZCWNNNCJM-UHFFFAOYSA-N
• SMILES: Cc1ccc(Cc2c(C)nc3c(C(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)cnn3c2C)cc1

RUVBL1/2 ATPase-IN-1靶点实验

查看更多实验

实验名称：Anti-proliferative activity against human HCT-116 assessed as cell growth inhibition ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5147194

实验名称：Anti-proliferative activity against human H1795 assessed as cell growth inhibition me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147195

实验名称：Anti-proliferative activity against human MDA-MB-231 assessed as cell growth inhibiti... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL5147196

实验名称：Inhibition of full length recombinant His6 tagged human RUVBL1 expressed in Escherich... 来源：ChEMBL 靶标：RuvB-like 1 External Id：CHEMBL5147190

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Inhibition of full length recombinant His6 tagged human RUVBL2 expressed in Escherich... 来源：ChEMBL 靶标：RuvB-like 2 External Id：CHEMBL5147191

实验名称：Inhibition of full length recombinant His6 tagged human RUVBL1/2 expressed in Escheri... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147192

实验名称：Anti-proliferative activity against human A549 assessed as cell growth inhibition mea... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5147193

共10条，当前第1页，共1页

1