BAY-4931

• 常用名: BAY-4931
• 英文名: BAY-4931
• CAS号: 423150-91-8
• 分子量: 421.83
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₆ClN₃O₄
• 熔点: N/A
• 闪点: N/A

BAY-4931用途

BAY-4931是一种强效、共价和选择性PPARγ反向激动剂,IC50为0.17nM[1]。

BAY-4931名称

• 英文名: BAY-4931

BAY-4931生物活性

• 描述: BAY-4931是一种强效、共价和选择性PPARγ反向激动剂,IC50为0.17nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
• 靶点实验:

  PPAR-γ:0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay)

  mouse PPARγ:0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

  hPPARγ:0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

• 体外研究: BAY-4931(0-10μM；7天)抑制UM-UC-9增殖,IC50为3.4 nM[1]。BAY-4931在CYP抑制试验中仅抑制CYP2C8[1]。细胞增殖测定[1]细胞系：UM-UC-9细胞浓度：0-10μM培养时间：7天结果：抑制增殖,IC50为3.4 nM。

BAY-4931物理化学性质

• 分子式: C₂₂H₁₆ClN₃O₄
• 分子量: 421.83
• InChIKey: WFEBALYYDASKIV-UHFFFAOYSA-N
• SMILES: CCc1ccc(-c2nc3cc(NC(=O)c4cc([N+](=O)[O-])ccc4Cl)ccc3o2)cc1

BAY-4931靶点实验

查看更多实验

实验名称：Inverse agonist activity at GAL4-tagged mouse PPARgamma LBD expressed in CHO cells me... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL5113082

实验名称：Inverse agonist activity at GAL4-tagged human PPARgamma LBD expressed in CHO cells me... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL5113084

实验名称：Efflux ratio of apparent permeability across basolateral to apical side to apparent p... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113078

实验名称：Thermodynamic solubility of the compound in PBS at pH 6.5 measured after 24 hrs by HP... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113079

实验名称：Covalent binding affinity to recombinant human PPARgamma at 5 uM measured by mass spe... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL5113080

实验名称：Stability of compound in 500 uM cysteine at pH 7.4 assessed as compound recovered at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113074

实验名称：Stability of compound in 500 uM cysteine at pH 7.4 assessed as compound recovered at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113075

实验名称：Stability of compound in 500 uM cysteine at pH 7.4 assessed as compound recovered at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113076

实验名称：Apparent permeability of the compound across apical side to basolateral side in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113077

实验名称：Stability of compound in 500 uM glutathione at pH 7.4 assessed as compound recovered ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5113070

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