醋酸环丙孕酮

• 常用名: 醋酸环丙孕酮
• 英文名: Cyproterone acetate
• CAS号: 427-51-0
• 分子量: 402.91
• 密度: 1.3±0.1 g/cm3
• 沸点: 525.9±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇ClO₄
• 熔点: 200-201ºC
• 闪点: 177.6±29.1 °C
• 符号: GHS07, GHS08
• 信号词: Warning

醋酸环丙孕酮用途

Cyproterone醋酸盐是高活性雄激素受体（AR）拮抗剂，IC50为7.1 nM，还是弱的孕酮受体激动剂。

醋酸环丙孕酮作用

抗雄性激素，用于治疗男性良性前列腺肥大症，并可用作男性避孕药

醋酸环丙孕酮名称

• 中文名: 环丙氯地孕酮
• 英文名: cyproterone acetate
• 中文别名: 醋酸环丙孕酮 | 醋酸环丙孕酮 | 环丙孕酮醋酸盐 | 6-氯-1α,2α-亚甲基-4,6-孕甾二烯-17α-羟基-3,20-二酮-17-醋酸酯 | 奈非西坦

醋酸环丙孕酮生物活性

• 描述: Cyproterone醋酸盐是高活性雄激素受体(AR)拮抗剂,IC50为7.1 nM,还是弱的孕酮受体激动剂。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 内分泌
• 参考文献:

  [1]. Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83(1): p. 136-48.

  [2]. Attardi, B.J., S. Koduri, and S.A. Hild, Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell End

  [3]. Arafa, N.M., Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol Sci, 2010. 13(20): p. 966-76.

醋酸环丙孕酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 525.9±50.0 °C at 760 mmHg
• 熔点: 200-201ºC
• 分子式: C₂₃H₂₇ClO₄
• 分子量: 402.91
• 闪点: 177.6±29.1 °C
• PSA: 60.44000
• LogP: 3.28
• 外观性状: 气味
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.582
• 储存条件: 2-8°C
• 水溶解性: Practically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.6

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:3

  5.互变异构体数量:10

  6.拓扑分子极性表面积:60.4

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:903

  10.同位素原子数量:0

  11.确定原子立构中心数量:8

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

醋酸环丙孕酮毒性和生态

醋酸环丙孕酮安全信息

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H312 + H332-H351
• 警示性声明: P261-P280
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R20/21/22;R40
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: GZ2230000
• 海关编码: 2937290090

醋酸环丙孕酮海关

• 海关编码: 2937290090

醋酸环丙孕酮英文别名

• Cyprostat
• (3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
• Cyprosterone acetate
• 6-Chloro-1b,2b-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-Acetate
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-, acetate
• Cyproterone 17-O-acetate
• Cyproteron acetate
• SH 714
• (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-Acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
• Cyproterone acetate
• androcur
• Cyproterone 17α-acetate
• (1b,2b)-17-(Acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• cPA
• Cyproteron-R acetate
• CpA (VAN)
• Cyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one, 1-acetyl-1-(acetyloxy)-5-chloro-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydro-8b,10a-dimethyl-, (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-
• Cyproterone (acetate)