珊塔玛内酯

• 常用名: 珊塔玛内酯
• 英文名: Santamarine
• CAS号: 4290-13-5
• 分子量: 248.318
• 密度: 1.2±0.1 g/cm3
• 沸点: 415.6±45.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 熔点: N/A
• 闪点: 176.5±21.5 °C

珊塔玛内酯用途

桑塔马林(Santamarine)是一种倍半萜内酯,通过Nrf2易位增加HO-1的表达,并通过抑制LPS诱导的巨噬细胞中的NF-κB易位抑制NO、PGE2、TNF-α和IL-1β的产生。桑塔马林通过抑制UVA照射的人皮肤成纤维细胞(HDF)中的MAPK/AP-1和刺激TGF-β/Smad信号而显示抗光老化特性。抗氧化活性[1][2]。

珊塔玛内酯名称

• 中文名: 裂叶苣荚莱内酯
• 英文名: santamarin

珊塔玛内酯生物活性

• 描述: 桑塔马林(Santamarine)是一种倍半萜内酯,通过Nrf2易位增加HO-1的表达,并通过抑制LPS诱导的巨噬细胞中的NF-κB易位抑制NO、PGE2、TNF-α和IL-1β的产生。桑塔马林通过抑制UVA照射的人皮肤成纤维细胞(HDF)中的MAPK/AP-1和刺激TGF-β/Smad信号而显示抗光老化特性。抗氧化活性[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Choi HG, et al. Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol. 2012;13(3):271-279.

  [2]. Oh JH, et al. Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs. Molecules. 2021;26(12):3585. Published 2021 Jun 11.

珊塔玛内酯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 415.6±45.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 分子量: 248.318
• 闪点: 176.5±21.5 °C
• 精确质量: 248.141251
• PSA: 46.53000
• LogP: 1.94
• InChIKey: PLSSEPIRACGCBO-PFFFPCNUSA-N
• SMILES: C=C1C(=O)OC2C1CCC1(C)C(O)CC=C(C)C21
• 外观性状: 粉末
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.555
• 储存条件: 2-8℃，干燥，密闭

珊塔玛内酯安全信息

• 危害码 (欧洲): Xi

珊塔玛内酯靶点实验

查看更多实验

实验名称：Inhibition of serotonin release in bovine platelets 来源：ChEMBL 靶标：Platelet External Id：CHEMBL952132

实验名称：Activation of PKM2 (unknown origin) at 3 uM incubated for 30 mins relative to control 来源：ChEMBL 靶标：Pyruvate kinase PKM External Id：CHEMBL5340268

实验名称：Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-huma... 来源：ChEMBL 靶标：T-cell External Id：CHEMBL4393627

实验名称：Inhibition of NF-kappaB DNA binding by EMSA 来源：ChEMBL 靶标：Transcription factor p65 External Id：CHEMBL861583

实验名称：Growth inhibition of human LS174T cells incubated for 72 hrs by methylene blue staini... 来源：ChEMBL 靶标：LS174T External Id：CHEMBL4818071

实验名称：Growth inhibition of human MCF7 cells incubated for 72 hrs by methylene blue staining... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4818072

实验名称：Immunomodulatory activity in C57BL/6 mouse mesenteric lymph node T cells assessed as ... 来源：ChEMBL 靶标：T-cell External Id：CHEMBL5340265

实验名称：Growth inhibition of human CCRF-CEM cells incubated for 24 to 48 hrs by trypan blue e... 来源：ChEMBL 靶标：CCRF-CEM External Id：CHEMBL4818069

实验名称：Growth inhibition of human KB cells incubated for 72 hrs by methylene blue staining b... 来源：ChEMBL 靶标：KB External Id：CHEMBL4818070

实验名称：Effect of compound (25 mg/kg) on Blood Ethanol level in Ethanol loaded rats after 1 h... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL775964

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珊塔玛内酯英文别名

• (3aS,5aR,6R,9aS,9bS)-6-hydroxy-5a,9-dimethyl-3-methylidene-3a,4,5,5a,6,7,9a,9b-octahydronaphtho[1,2-b]furan-2(3H)-one
• Santamarin
• (3aS,5aR,6R,9aS,9bS)-6-Hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,9a,9b-octahydronaphtho[1,2-b]furan-2(3H)-one
• Balchanin
• (3aS,5aR,6R,9aS,9bS)-6-hydroxy-5a,9-dimethyl-3-methylidene-4,5,6,7,9a,9b-hexahydro-3aH-benzo[g][1]benzofuran-2-one