(S)-Butaprost free acid

• 常用名: (S)-Butaprost free acid
• 英文名: (S)-Butaprost free acid
• CAS号: 433219-55-7
• 分子量: 394.545
• 密度: 1.1±0.1 g/cm3
• 沸点: 565.7±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₈O₅
• 熔点: N/A
• 闪点: 310.0±26.6 °C

(S)-Butaprost free acid用途

(S) -Butaprost(游离酸)是一种有效且高度选择性的EP2受体激动剂[1]。

(S)-Butaprost free acid名称

• 英文名: (+/-)-15-deoxy-16r-hydroxy-17-cyclobutyl prostaglandin e1

(S)-Butaprost free acid生物活性

• 描述: (S) -Butaprost(游离酸)是一种有效且高度选择性的EP2受体激动剂[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
• 靶点实验:

  EP2[1]

• 参考文献:

  [1]. Tani K, et al. Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives. Bioorg Med Chem. 2002;10(4):1107-1114.

(S)-Butaprost free acid物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 565.7±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₈O₅
• 分子量: 394.545
• 闪点: 310.0±26.6 °C
• 精确质量: 394.271912
• PSA: 94.83000
• LogP: 3.04
• InChIKey: PAYNQYXOKJDXAV-ZHIWTBQHSA-N
• SMILES: CCCC1(C(O)CC=CC2C(O)CC(=O)C2CCCCCCC(=O)O)CCC1
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.558

(S)-Butaprost free acid靶点实验

查看更多实验

实验名称：Human TP receptor (Prostanoid receptors) 来源：IUPHAR-DB 靶标：TP receptor (Prostanoid receptors) [Homo sapiens] External Id：346_Human

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Rat EP4 receptor (Prostanoid receptors) 来源：IUPHAR-DB 靶标：EP4 receptor (Prostanoid receptors) [Rattus norvegicus] External Id：343_Rat

实验名称：Rat EP3 receptor (Prostanoid receptors) 来源：IUPHAR-DB 靶标：EP3 receptor (Prostanoid receptors) [Rattus norvegicus] External Id：342_Rat

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Binding affinity to EP2 receptor (unknown origin) by competitive binding assay 来源：ChEMBL 靶标：Prostaglandin E2 receptor EP2 subtype External Id：CHEMBL3294240

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Human EP4 receptor (Prostanoid receptors) 来源：IUPHAR-DB 靶标：EP4 receptor (Prostanoid receptors) [Homo sapiens] External Id：343_Human

实验名称：Human EP2 receptor (Prostanoid receptors) 来源：IUPHAR-DB 靶标：EP2 receptor (Prostanoid receptors) [Homo sapiens] External Id：341_Human

实验名称：Binding affinity to EP3 receptor (unknown origin) 来源：ChEMBL 靶标：Prostaglandin E2 receptor EP3 subtype External Id：CHEMBL3294242

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(S)-Butaprost free acid英文别名

• 9-oxo-11alpha,16s-dihydroxy-17-cyclobutyl-prost-13e-en-1-oic acid
• 9-oxo-11alpha,16r-dihydroxy-17-cyclobutyl-prost-13e-en-1-oic acid
• 7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxocyclopentyl}heptanoic acid
• (11α,13E,16S)-11,16-Dihydroxy-9-oxo-17-propyl-17,20-cycloprost-13-en-1-oic acid
• (11α,13E,16R)-11,16-Dihydroxy-9-oxo-17-propyl-17,20-cycloprost-13-en-1-oic acid