BRD32048

• 常用名: BRD32048
• 英文名: BRD32048
• CAS号: 433694-46-3
• 分子量: 314.385
• 密度: 1.3±0.1 g/cm3
• 沸点: 545.3±60.0 °C at 760 mmHg
• 分子式: C₁₆H₂₂N₆O
• 熔点: N/A
• 闪点: 283.6±32.9 °C

BRD32048用途

BRD32048是ETV1的直接粘合剂,KD为17.1μM。BRD32048调节ETV1介导的转录活性和ETV1驱动的癌细胞的侵袭。BRD32048抑制ETV1乙酰化并促进其降解。BRD32048是ETV1扰动因子的首选候选者【1】。

BRD32048名称

• 英文名: brd32048

BRD32048生物活性

• 描述: BRD32048是ETV1的直接粘合剂,KD为17.1μM。BRD32048调节ETV1介导的转录活性和ETV1驱动的癌细胞的侵袭。BRD32048抑制ETV1乙酰化并促进其降解。BRD32048是ETV1扰动因子的首选候选者【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 参考文献:

  [1]. Marius S Pop, et al. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Mol Cancer Ther. 2014 Jun;13(6):1492-502.

BRD32048物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 545.3±60.0 °C at 760 mmHg
• 分子式: C₁₆H₂₂N₆O
• 分子量: 314.385
• 闪点: 283.6±32.9 °C
• 精确质量: 314.185516
• PSA: 89.19000
• LogP: 1.23
• InChIKey: PVHJDJWPRZUURH-UHFFFAOYSA-N
• SMILES: COc1ccc(Nc2nc(N)nc(CN3CCCCC3)n2)cc1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.650

BRD32048安全信息

• 危险品运输编码: NONH for all modes of transport

BRD32048靶点实验

查看更多实验

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实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

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BRD32048英文别名

• N-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine