4,4'-二甲基-[1,1'-联苯]-2,2',5,5'-四醇

• 常用名: 4,4'-二甲基-[1,1'-联苯]-2,2',5,5'-四醇
• 英文名: 4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol
• CAS号: 4371-34-0
• 分子量: 246.25900
• 密度: 1.36g/cm3
• 沸点: 501.6ºC at 760 mmHg
• 分子式: C₁₄H₁₄O₄
• 熔点: N/A
• 闪点: 248.2ºC

用途

NSC2805是WWP2泛素连接酶抑制剂,其IC50为0.38μM,可显著抑制WWP2活性。NSC2805可用于癌症研究[1]。

名称

• 中文名: 4,4'-二甲基-[1,1'-联苯]-2,2',5,5'-四醇
• 英文名: 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol

生物活性

• 描述: NSC2805是WWP2泛素连接酶抑制剂,其IC50为0.38μM,可显著抑制WWP2活性。NSC2805可用于癌症研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: NSC2805具有WWP2抑制活性,IC50为0.38μM[1]。NSC2805显示所有三种蛋白质(WWP2、WWP1和Nedd4)的活性都显著降低[1]。NSC2805能强烈抑制WWP2依赖性PTEN泛素化[1]。
• 参考文献:

  [1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680.

物理化学性质

• 密度: 1.36g/cm3
• 沸点: 501.6ºC at 760 mmHg
• 分子式: C₁₄H₁₄O₄
• 分子量: 246.25900
• 闪点: 248.2ºC
• 精确质量: 246.08900
• PSA: 80.92000
• LogP: 2.79280
• InChIKey: DSVRCBOSZSZMRX-UHFFFAOYSA-N
• SMILES: Cc1cc(O)c(-c2cc(O)c(C)cc2O)cc1O
• 折射率: 1.675
• 储存条件: 室温

安全信息

• 海关编码: 2906299090

海关

• 海关编码: 2906299090
• 中文概述: 2906299090 其他芳香醇. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

靶点实验

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英文别名

• 4.4'-Dimethyl-biphenyltetrol-(2.5.2'.5')
• 2.5.2'.5'-Tetraoxy-4.4'-dimethyl-diphenyl
• 2.5.2'.5'-Tetrahydroxy-4.4'-dimethyl-biphenyl
• 2.5.2'.5'-Tetraoxy-ditolyl-(4.4')
• 4,4'-dimethyl[1,1'-biphenyl]-2,2',5,5'-tetrol
• 4,4'-Dimethyl-biphenyl-2,5,2',5'-tetraol