龙胆碱

• 常用名: 龙胆碱
• 英文名: Gentianine
• CAS号: 439-89-4
• 分子量: 175.184
• 密度: 1.2±0.1 g/cm3
• 沸点: 386.5±42.0 °C at 760 mmHg
• 分子式: C₁₀H₉NO₂
• 熔点: 84-86ºC
• 闪点: 187.6±27.9 °C

龙胆碱用途

Gentianine 是一种有效的 Swertiamarin 代谢产物,具有抗糖尿病和抗炎作用。

龙胆碱名称

• 中文名: 秦艽甲素
• 英文名: gentianine

龙胆碱生物活性

• 描述: Gentianine 是一种有效的 Swertiamarin 代谢产物,具有抗糖尿病和抗炎作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Vaidya H, et al. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytother Res. 2013 Apr;27(4):624-7.

  [2]. Wenjin C, et al. Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's Complete Adjuvant-Induced Arthritis in Rats. Inflammation. 2017 Aug;40(4):1401-1408.

龙胆碱物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 386.5±42.0 °C at 760 mmHg
• 熔点: 84-86ºC
• 分子式: C₁₀H₉NO₂
• 分子量: 175.184
• 闪点: 187.6±27.9 °C
• 精确质量: 175.063324
• PSA: 39.19000
• LogP: 1.73
• InChIKey: DFNZYFAJQPLJFI-UHFFFAOYSA-N
• SMILES: C=Cc1cncc2c1CCOC2=O
• 外观性状: 粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.604
• 储存条件: 2-8℃，干燥，密闭

龙胆碱毒性和生态

龙胆碱安全信息

• 危害码 (欧洲): Xi

龙胆碱靶点实验

查看更多实验

实验名称：Antipsychotic activity in albino mouse assessed as potentiation of hexobarbital-induc... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4676788

实验名称：Antipsychotic activity in trained mouse assessed as reduction in ability of mouse to ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4676787

实验名称：Antipsychotic activity in mouse assessed as reduction in amphetamine-induced toxicity 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4676789

实验名称：Toxicity in ip dosed albino rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676782

实验名称：Potentiation of diphenylhydantoin-induced anticonvulsant activity in rat relative to ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4676784

实验名称：Protection against pentylenetetrazol-induced convulsion in rat at 50 to 100 mg/kg, ip... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4676783

实验名称：Antiaggressive activity in mouse assessed as reduction in foot shock induced fighting... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4676786

实验名称：Potentiation of morphine-induced analgesia in rat relative to control 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4676785

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龙胆碱英文别名

• 4-(2-hydroxyethyl)-5-vinylnicotinic acid δ-lactone
• 4-<2-Hydroxyaethyl>-5-vinyl-3-pyridin-carboxylic acid lacton
• 5-VINYLPYRROLIDONE
• 4-(2-Hydroxyethyl)-5-vinylnicotinic lactone
• 5-Ethenyl-3,4-dihydro-1H-pyrano(3,4-c)pyridin-1-one
• Gentianine
• 4-(2-Hydroxyethyl)-5-vinylnicotinic Acid d-Lactone
• 5-vinylpyrrolidinone
• 2-Pyrrolidinone,5-ethenyl
• Erythricine
• 5-vinyl-pyrrolidin-2-one
• UNII-C2PD310UXB
• 5-ethenyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one
• 5-Vinyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one