Vapendavir

• 常用名: Vapendavir
• 英文名: Vapendavir
• CAS号: 439085-51-5
• 分子量: 382.45600
• 密度: 1.191±0.06 g/cm3(Predicted)
• 沸点: 612.0±55.0 °C(Predicted)
• 分子式: C₂₁H₂₆N₄O₃
• 熔点: N/A
• 闪点: N/A

Vapendavir用途

Vapendavir (BTA798) 是一种有效的肠病毒衣壳粘合剂 (CB)。Vapendavir (BTA798) 可抑制EV71 的复制,对EV71 不同毒株的EC50 值为0.5-1.4 μM。

Vapendavir名称

• 中文名: 3-乙氧基-6-(2-(1-(6-甲基哒嗪-3-基)哌啶-4-基)乙氧基)苯并[D]异恶唑
• 英文名: 3-ethoxy-6-[2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy]-1,2-benzoxazole

Vapendavir生物活性

• 描述: Vapendavir (BTA798) 是一种有效的肠病毒衣壳粘合剂 (CB)。Vapendavir (BTA798) 可抑制EV71 的复制,对EV71 不同毒株的EC50 值为0.5-1.4 μM。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 肠道病毒
• 靶点实验:

  EC50: 0.5-1.4 μM (EV71 strains)[1][2].

• 参考文献:

  [1]. Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2.

  [2]. Sun L, et al. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5.

Vapendavir物理化学性质

• 密度: 1.191±0.06 g/cm3(Predicted)
• 沸点: 612.0±55.0 °C(Predicted)
• 分子式: C₂₁H₂₆N₄O₃
• 分子量: 382.45600
• 精确质量: 382.20000
• PSA: 73.51000
• LogP: 4.07540
• InChIKey: DKSVBVKHUICELN-UHFFFAOYSA-N
• SMILES: CCOc1noc2cc(OCCC3CCN(c4ccc(C)nn4)CC3)ccc12
• 外观性状: 白色固体
• 储存条件: 室温

Vapendavir靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：ASTRAZENECA: Solubility in pH7.4 buffer using solid starting material using the metho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301364

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301367

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301366

实验名称：Resistance index, ratio of EC50 for Human rhinovirus B14 harboring VP1 A150V/E276K do... 来源：ChEMBL 靶标：rhinovirus B14 External Id：CHEMBL4012814

实验名称：Resistance index, ratio of EC50 for Human rhinovirus B14 harboring VP1 C199Y mutant i... 来源：ChEMBL 靶标：rhinovirus B14 External Id：CHEMBL4012815

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Vapendavir英文别名

• 3-Ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzisoxazole
• Vapendavir [INN]
• Vapendavir
• UNII-Q8LVL5Z68H
• 3-Ethoxy-6-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)-1,2-benzoxazole