Talaglumetad hydrochloride

• 常用名: Talaglumetad hydrochloride
• 英文名: Talaglumetad hydrochloride
• CAS号: 441765-97-5
• 分子量: 292.71600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₇ClN₂O₅
• 熔点: N/A
• 闪点: N/A

Talaglumetad hydrochloride用途

盐酸塔格列美他是II型代谢型谷氨酸受体(mGluR2/3)激动剂Eglumegad治疗焦虑症的前药。

Talaglumetad hydrochloride名称

• 英文名: (1S,2S,5R,6S)-2-[[(2S)-2-aminopropanoyl]amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,hydrochloride

Talaglumetad hydrochloride生物活性

• 描述: 盐酸塔格列美他是II型代谢型谷氨酸受体(mGluR2/3)激动剂Eglumegad治疗焦虑症的前药。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kellner M, Muhtz C, Stark K, Yassouridis A, Arlt J, Wiedemann K. Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl). 2005;179(1):310-315.

  [2]. Varma MV, Eriksson AH, Sawada G, Pak YA, Perkins EJ, Zimmerman CL. Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344). Drug Metab Dispos. 2009;37(1):211-220.

  [3]. Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther. 2006;316(2):905-913.

Talaglumetad hydrochloride物理化学性质

• 分子式: C₁₁H₁₇ClN₂O₅
• 分子量: 292.71600
• 精确质量: 292.08300
• PSA: 133.21000
• LogP: 1.35640
• InChIKey: TWZDLCLCMKMJPE-OAOSNHGPSA-N
• SMILES: CC(N)C(=O)NC1(C(=O)O)CCC2C(C(=O)O)C21.Cl

Talaglumetad hydrochloride靶点实验

查看更多实验

实验名称：Onset of suppression of startle of compound in rat fear-potentiated startle assay at ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL827444

实验名称：Area under concentration of compound in rats at a dose of 5 mg equiv 1/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL839500

实验名称：Plasma concentration of LY-354740 in rats after oral administration of compound at a ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL829368

实验名称：Oral bioavailability in rat (dose 5 mg equiv/kg) 来源：ChEMBL 靶标：N/A External Id：CHEMBL825255

实验名称：Duration of suppression of compound in rat fear-potentiated startle assay at an oral ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL836524

实验名称：Plasma concentration of LY-354740 in rats after oral administration of compound at a ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL875078

实验名称：Minimally effective dose for suppression of startle in rat fear-potentiated startle a... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL830470

实验名称：Duration of suppression of compound in rat fear-potentiated startle assay at an oral ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL836523

实验名称：Plasma concentration of LY-354740 in rats after oral administration of compound at a ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL830035

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Talaglumetad hydrochloride英文别名

• Talaglumetad hydrochloride (USAN)
• Talaglumetad hydrochloride
• Bicyclo(310)hexane-2,6-dicarboxylic acid,2-(((2S)-2-amino-1-oxopropyl)amino)-,monohydrochloride,(1S,2S,5R,6S)
• Talaglumetad HCl