AG-205

• 常用名: AG-205
• 英文名: AG-205
• CAS号: 442656-02-2
• 分子量: 454.97600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃ClN₆OS
• 熔点: N/A
• 闪点: N/A

AG-205用途

(rac)-AG-205是孕激素受体膜组分1(Pgrmc1)的有效抑制剂,其诱导参与甾醇合成的基因,包括INSIG1蛋白,其与Pgrmc1形成复合物。(rac)-AG-205通过阻断NF-kB信号传导和BDNF/PI3K/AKT通路的激活来防止神经元对缺氧缺血的抵抗[1]。

AG-205名称

• 英文名: 2-[1-(4-chlorophenyl)tetrazol-5-yl]sulfanyl-1-(2,8-dimethyl-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]indol-5-yl)ethanone

AG-205生物活性

• 描述: (rac)-AG-205是孕激素受体膜组分1(Pgrmc1)的有效抑制剂,其诱导参与甾醇合成的基因,包括INSIG1蛋白,其与Pgrmc1形成复合物。(rac)-AG-205通过阻断NF-kB信号传导和BDNF/PI3K/AKT通路的激活来防止神经元对缺氧缺血的抵抗[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 参考文献:

  [1]. Cahill MA. Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins. Front Biosci (Landmark Ed). 2022 Nov 30;27(11):317

AG-205物理化学性质

• 分子式: C₂₂H₂₃ClN₆OS
• 分子量: 454.97600
• 精确质量: 454.13400
• PSA: 92.45000
• LogP: 3.55360
• InChIKey: GJNBAISSZRNGTM-UHFFFAOYSA-N
• SMILES: Cc1ccc2c(c1)C1CN(C)CCC1N2C(=O)CSc1nnnn1-c1ccc(Cl)cc1

AG-205靶点实验

查看更多实验

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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AG-205英文别名

• ag-205