R1487盐酸盐

• 常用名: R1487盐酸盐
• 英文名: R1487 Hydrochloride
• CAS号: 449808-64-4
• 分子量: 424.829
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₉ClF₂N₄O₃
• 熔点: N/A
• 闪点: N/A

R1487盐酸盐用途

R1487 (Hydrochloride)是一个强的和高的选择性的p38α抑制剂。

R1487盐酸盐名称

• 中文名: R1487盐酸盐
• 英文名: R1487 HCl

R1487盐酸盐生物活性

• 描述: R1487 (Hydrochloride)是一个强的和高的选择性的p38α抑制剂。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.

R1487盐酸盐物理化学性质

• 分子式: C₁₉H₁₉ClF₂N₄O₃
• 分子量: 424.829
• 精确质量: 424.111389
• PSA: 81.50000
• LogP: 3.21380
• InChIKey: RQHSAIGGUWVOBG-UHFFFAOYSA-N
• SMILES: Cl.Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21
• 储存条件: 2-8℃

R1487盐酸盐靶点实验

查看更多实验

实验名称：Clearance in Hanover-Wistar rat at 10 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1769344

实验名称：Half life in Beagle dog at 10 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1769451

实验名称：Oral bioavailability in Hanover-Wistar rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1769343

实验名称：Plasma protein binding in Hanover-Wistar rat by untrafiltration method 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1769346

实验名称：Oral bioavailability in Beagle dog at 10 mg/kg 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1769453

实验名称：Volume of distribution at steady state in Hanover-Wistar rat at 10 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1769345

实验名称：AUC (infinity) in Beagle dog at 10 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1769452

实验名称：Volume of distribution at steady state in Beagle dog at 10 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1769455

实验名称：Clearance in Beagle dog at 10 mg/kg, iv 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL1769454

实验名称：Plasma protein binding in Beagle dog by untrafiltration method 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1769456

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R1487盐酸盐英文别名

• 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride (1:1)
• R-1487 Hydrochloride
• Pyrido[2,3-d]pyrimidin-7(8H)-one,6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-,hydrochloride
• 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
• Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-, hydrochloride (1:1)
• QC-6149
• RS0052
• R1487 Hydrochloride