Topoisomerase II inhibitor 13

• 常用名: Topoisomerase II inhibitor 13
• 英文名: Topoisomerase II inhibitor 13
• CAS号: 451515-89-2
• 分子量: 413.48
• 密度: 1.4±0.1 g/cm3
• 沸点: 715.0±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₃N₉
• 熔点: N/A
• 闪点: 386.2±35.7 °C

Topoisomerase II inhibitor 13用途

拓扑异构酶II抑制剂13是一种拓扑异酶II(Topo II)抑制剂。拓扑异构酶II抑制剂13对几种癌症细胞具有抗增殖活性。拓扑异构酶II抑制剂13诱导癌症细胞凋亡[1]。

Topoisomerase II inhibitor 13名称

• 英文名: WAY-323966

Topoisomerase II inhibitor 13生物活性

• 描述: 拓扑异构酶II抑制剂13是一种拓扑异酶II(Topo II)抑制剂。拓扑异构酶II抑制剂13对几种癌症细胞具有抗增殖活性。拓扑异构酶II抑制剂13诱导癌症细胞凋亡[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
• 靶点实验:

  Topoisomerase II

• 体外研究: 拓扑异构酶II抑制剂13(化合物3m)(20μM,50μM)在 20微米时发挥强烈的抑制作用,几乎完全抑制 Topo II型活性[1] 拓扑异构酶II抑制剂13抑制癌细胞增殖,IC50分别为 25.85μM(MDA-MB-231)、1.82μM(A549)、10.38μM(K562)、1.73μM(Raji)、1.23μM(HL-60)和 0.87μM(HL-60/MX2)[1]
• 参考文献:

  [1]. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.

Topoisomerase II inhibitor 13物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 715.0±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₃N₉
• 分子量: 413.48
• 闪点: 386.2±35.7 °C
• 精确质量: 413.207642
• LogP: 3.27
• InChIKey: SZUYNNSSCOCFTF-UHFFFAOYSA-N
• SMILES: CCN(CC)CCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc(C#N)c(C#N)nc21
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.721
• 储存条件: -80℃储存

Topoisomerase II inhibitor 13靶点实验

查看更多实验

实验名称：A screen for compounds that inhibit cell wall-associated teichoic acid synthesis in S... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS704

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Antiproliferative activity against human K562 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL3760940

实验名称：Antiproliferative activity against human A549 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL3760939

实验名称：Antiproliferative activity against human MDA-MB-201 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3760938

实验名称：Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL3760937

实验名称：Resistance index, ratio of IC50 for human HL60/MX2 cells to IC50 for HL60 cells 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL3760944

实验名称：Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3760943

实验名称：Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3760942

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Topoisomerase II inhibitor 13英文别名

• 6-Amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile
• TCMDC-123680