EGFR-IN-52

• 常用名: EGFR-IN-52
• 英文名: EGFR-IN-52
• CAS号: 454436-75-0
• 分子量: 382.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₈N₄O₃S
• 熔点: N/A
• 闪点: N/A

EGFR-IN-52用途

EGFR-IN-52(化合物4)是一种有效的EGFR抑制剂,对EGFR、EGFR L858R-TK和EGFR T790M-TK的IC50值分别为0.358、86.02和432.67µM。EGFR-IN-52显示出对癌细胞系的细胞毒活性并诱导凋亡[1]。

EGFR-IN-52名称

• 英文名: EGFR-IN-52

EGFR-IN-52生物活性

• 描述: EGFR-IN-52(化合物4)是一种有效的EGFR抑制剂,对EGFR、EGFR L858R-TK和EGFR T790M-TK的IC50值分别为0.358、86.02和432.67µM。EGFR-IN-52显示出对癌细胞系的细胞毒活性并诱导凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  EGFR:0.358 μM (IC50)

  EGFRL858R:86.02 μM (IC50)

  EGFRT790M:432.67 μM (IC50)

• 参考文献:

  [1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

EGFR-IN-52物理化学性质

• 分子式: C₁₉H₁₈N₄O₃S
• 分子量: 382.44
• InChIKey: ZNMSKFVKBVCPAJ-UHFFFAOYSA-N
• SMILES: Cc1c(NC(=S)Nc2ccc3c(c2)OCO3)c(=O)n(-c2ccccc2)n1C

EGFR-IN-52靶点实验

查看更多实验

实验名称：Induction of apoptosis in human HepG2 cells assessed as Bax level (Rvb = 27.35 pg/ml) 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769442

实验名称：Induction of apoptosis in human HepG2 cells assessed as Bcl2 level (Rvb = 6.639 pg/ml... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769443

实验名称：Induction of cell cycle arrest in human HepG2 cells assessed as G2/M phase accumulati... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769440

实验名称：Induction of cell cycle arrest in human HepG2 cells assessed as preG1 phase accumulat... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769441

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 5 uM... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769434

实验名称：Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 5 uM ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769435

实验名称：Induction of cell cycle arrest in human HepG2 cells assessed as G0/G1 phase accumulat... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769438

实验名称：Induction of cell cycle arrest in human HepG2 cells assessed as S phase accumulation ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4769439

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

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