NSC 15364

• 常用名: NSC 15364
• 英文名: NSC 15364
• CAS号: 4550-72-5
• 分子量: 242.277
• 密度: 1.4±0.1 g/cm3
• 沸点: 381.4±27.0 °C at 760 mmHg
• 分子式: C₁₃H₁₄N₄O
• 熔点: N/A
• 闪点: 184.5±23.7 °C

NSC 15364用途

NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。

NSC 15364名称

• 英文名: 1,3-bis(4-aminophenyl)urea

NSC 15364生物活性

• 描述: NSC 15364 是一种 VDAC1 寡聚化和细胞凋亡 (apoptosis) 抑制剂。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 心血管疾病
  研究领域 >> 神经疾病
• 体外研究: 线粒体膜蛋白电压依赖性负离子通道1(VDAC1)齐聚是设计用于调节凋亡的药物的主要靶点[1]。
• 参考文献:

  [1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

NSC 15364物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 381.4±27.0 °C at 760 mmHg
• 分子式: C₁₃H₁₄N₄O
• 分子量: 242.277
• 闪点: 184.5±23.7 °C
• 精确质量: 242.116760
• PSA: 93.17000
• LogP: -0.50
• 外观性状: 白色固体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.785
• 储存条件: -20℃

NSC 15364安全信息

• 海关编码: 2924299090

NSC 15364海关

• 海关编码: 2924299090
• 中文概述: 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

NSC 15364靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Identifying Sarm1 TIR NADase inhibitors through high throughput HPLC assay 来源：24386 靶标：N/A External Id：Sarm1 TIR NADase inhibitors

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

共115条，当前第1页，共12页

1

2

3

4

5

NSC 15364英文别名

• 1,3-Bis(p-aminophenyl)urea
• N,N'-Bis(4-aminophenyl)urea
• 1,3-bis-(4-aminophenyl)urea
• 1,3-Bis(4-aminophenyl)urea
• 4,4'-diaminodiphenylurea
• Carbanilide,4'-diamino
• NSC 15364