SW033291

• 常用名: SW033291
• 英文名: SW 033291
• CAS号: 459147-39-8
• 分子量: 412.591
• 密度: 1.4±0.1 g/cm3
• 沸点: 670.1±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀N₂OS₃
• 熔点: N/A
• 闪点: 359.0±31.5 °C
• 符号: GHS07
• 信号词: Warning

SW033291用途

SW033291是15-PGDH小分子抑制剂，Ki值0.1nM，组织修复功能。

SW033291名称

• 中文名: SW033291
• 英文名: 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine

SW033291生物活性

• 描述: SW033291是15-PGDH小分子抑制剂,Ki值0.1nM,组织修复功能。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 15-PGDH
  研究领域 >> 其他
• 参考文献:

  [1]. Zhang Y, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 12;348(6240):aaa2340.

SW033291物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 670.1±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀N₂OS₃
• 分子量: 412.591
• 闪点: 359.0±31.5 °C
• 精确质量: 412.073761
• LogP: 5.47
• InChIKey: LCYAYKSMOVLVRL-UHFFFAOYSA-N
• SMILES: CCCCS(=O)c1sc2nc(-c3cccs3)cc(-c3ccccc3)c2c1N
• 外观性状: 粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.741
• 储存条件: -20℃

SW033291安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

SW033291靶点实验

查看更多实验

实验名称：In Vitro Assay from US Patent US9790233: "Compositions and methods of modulating 15-P... 来源：BindingDB 靶标：N/A External Id：BindingDB_1967_1

实验名称：Plasma concentration in CD1 mouse at 10 mg/kg, ip measured at 3 hrs post dose by LC-M... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4051499

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of 15-PGDH in human A549 cells assessed as increase in IL-1beta-stimulated... 来源：ChEMBL 靶标：15-hydroxyprostaglandin dehydrogenase [NAD(+)] External Id：CHEMBL4051489

实验名称：Inhibition of 15-PGDH in human A549 cells assessed as increase in IL-1beta-stimulated... 来源：ChEMBL 靶标：15-hydroxyprostaglandin dehydrogenase [NAD(+)] External Id：CHEMBL4051490

实验名称：Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escheric... 来源：ChEMBL 靶标：15-hydroxyprostaglandin dehydrogenase [NAD(+)] External Id：CHEMBL4051488

实验名称：Confirmatory qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC 靶标：N/A External Id：APP-Toga-CHIKV-nsP2-f2-f9

实验名称：Selectivity profile for inhibitors of NSP2Pro chikungunya virus (CHIKV): Papain Count... 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-f3_f16

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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SW033291英文别名

• 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-amine
• SW-033291
• SW033291