PEAQX

• 常用名: PEAQX
• 英文名: NVP-AAM077
• CAS号: 459836-30-7
• 分子量: 454.212
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₇H₁₇BrN₃O₅P
• 熔点: N/A
• 闪点: N/A

PEAQX用途

PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂，IC50值为270nM。

PEAQX名称

• 中文名: PEAQX
• 英文名: PEAQX

PEAQX生物活性

• 描述: PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.

  [2]. Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.

  [3]. Yu X, et al. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. 2018 Nov 1;391:1-12.

PEAQX物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₇H₁₇BrN₃O₅P
• 分子量: 454.212
• 精确质量: 453.008911
• LogP: 0.80
• InChIKey: XXZGNAZRWCBSBK-WFVOFKTRSA-N
• SMILES: CC(NC(c1cccc2[nH]c(=O)c(=O)[nH]c12)P(=O)(O)O)c1ccc(Br)cc1
• 折射率: 1.647
• 储存条件: 2-8℃

PEAQX靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Anticonvulsant effect in mouse electroshock-induced seizure test (MES). 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722509

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human ... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2A External Id：CHEMBL750561

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PEAQX英文别名

• PEAQX
• [{[(1S)-1-(4-Bromophenyl)ethyl]amino}(2,3-dioxo-1,2,3,4-tetrahydro-5-quinoxalinyl)methyl]phosphonic acid
• NVP-AAM077