沙蟾蜍精

• 常用名: 沙蟾蜍精
• 英文名: Arenobufagin
• CAS号: 464-74-4
• 分子量: 416.507
• 密度: 1.4±0.1 g/cm3
• 沸点: 637.2±55.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂O₆
• 熔点: N/A
• 闪点: 219.3±25.0 °C

沙蟾蜍精用途

沙蟾蜍精(Arenobufagin)是由蟾蜍毒液提取的蟾蜍甾烯，具有抗癌活性。

沙蟾蜍精名称

• 中文名: 沙蟾毒精
• 英文名: arenobufagin
• 中文别名: 沙蟾蜍精

沙蟾蜍精生物活性

• 描述: 沙蟾蜍精(Arenobufagin)是由蟾蜍毒液提取的蟾蜍甾烯,具有抗癌活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 类固醇
• 参考文献:

  [1]. Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42.

  [2]. Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60.

  [3]. Cruz Jdos S, et al. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6.

沙蟾蜍精物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 637.2±55.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.507
• 闪点: 219.3±25.0 °C
• 精确质量: 416.219879
• PSA: 107.97000
• LogP: 0.80
• InChIKey: JGDCRWYOMWSTFC-AZGSIFHYSA-N
• SMILES: CC12CCC(O)CC1CCC1C2C(O)C(=O)C2(C)C(c3ccc(=O)oc3)CCC12O
• 蒸汽压: 0.0±4.3 mmHg at 25°C
• 折射率: 1.622
• 储存条件: -20°C

沙蟾蜍精靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antiproliferative activity against human AC16 cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4267195

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as decrease in cel... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4039361

实验名称：Antiproliferative activity against human HepG2 cells by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4267194

实验名称：Antiproliferative activity against human HepG2/ADM cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4267197

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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沙蟾蜍精英文别名

• Arenobufagin
• (3β,5β,11α)-3,11,14-Trihydroxy-12-oxobufa-20,22-dienolide
• ARENOBUFAGIN (REFERENCE GRADE)