Antibacterial agent 121

• 常用名: Antibacterial agent 121
• 英文名: Antibacterial agent 121
• CAS号: 474099-18-8
• 分子量: 346.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₂N₂O₃S
• 熔点: N/A
• 闪点: N/A

Antibacterial agent 121用途

抗菌剂121(化合物10)是一种抗菌剂。抗菌剂121具有抗分枝杆菌和抗炎活性,可用于结核病(TB)研究[1]。

Antibacterial agent 121名称

• 英文名: Antibacterial agent 121

Antibacterial agent 121生物活性

• 描述: 抗菌剂121(化合物10)是一种抗菌剂。抗菌剂121具有抗分枝杆菌和抗炎活性,可用于结核病(TB)研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 抗菌剂121(0.2-200µM；24小时)抑制细菌培养物中结核分枝杆菌H37Rv的生长[1]。抗菌剂121(0-200µM；24小时)抑制LPS刺激的RAW 264.7细胞培养物中的NO生成,IC50值为4.1µM[1]。抗菌剂121(6.25-200µM,24小时)抑制LPS刺激的巨噬细胞中TNF-α和IL-1β的生成[1]。抗菌剂121(25-100µM,4 d)抑制结核分枝杆菌M299,MIC50值为24.8µM[1]。细胞活力测定[1]细胞株：结核分枝杆菌H37Rv浓度：0.2-200µM培养时间：24小时结果：抑制了结核分枝杆菌的H37Rv生长,MIC50为8.6µM。细胞活力测定[1]细胞系：RAW 264.7巨噬细胞和J774A。1巨噬细胞浓度：6.25-200µM培养时间：24小时结果：TNF-α和IL-1β生成的IC50值分别为15.3µM和28.4µM。
• 参考文献:

  [1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.

Antibacterial agent 121物理化学性质

• 分子式: C₁₈H₂₂N₂O₃S
• 分子量: 346.44

Antibacterial agent 121靶点实验

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实验名称：Selectivity index, ratio of CC50 for cytotoxicity against LPS-stimulated mouse RAW264... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5144866

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in mouse RA... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5144867

实验名称：Antitubercular activity against Mycobacterium tuberculosis M299 infected in mouse RAW... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5144868

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in mouse RA... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5144869

实验名称：Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5144862

实验名称：Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5144863

实验名称：Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5144864

实验名称：Antitubercular activity against Mycobacterium tuberculosis M299 assessed as reduction... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5144865

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against LPS-stimulated mouse RAW264... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5144858

实验名称：Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess re... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5144859

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