2-硝基-N-(4-(吡啶-2-基)噻唑-2-基)苯甲酰胺

• 常用名: 2-硝基-N-(4-(吡啶-2-基)噻唑-2-基)苯甲酰胺
• 英文名: Antitubercular agent-33
• CAS号: 476317-29-0
• 分子量: 326.330
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₅H₁₀N₄O₃S
• 熔点: N/A
• 闪点: N/A

用途

抗结核药物-33是一种2-氨基噻唑衍生物,对结核分枝杆菌(Mtb)具有强大的抗结核活性[1]。

名称

• 中文名: 2-硝基-N-(4-(吡啶-2-基)噻唑-2-基)苯甲酰胺
• 英文名: Benzamide, 2-nitro-N-[4-(2-pyridinyl)-2-thiazolyl]

生物活性

• 描述: 抗结核药物-33是一种2-氨基噻唑衍生物,对结核分枝杆菌(Mtb)具有强大的抗结核活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 抗结核药物-33(化合物49)具有抗结核作用,MIC值分别为1.6-3.1μM(在7H9葡萄糖介质中)和0.78μM(GAST介质中)[1]。
• 参考文献:

  [1]. Meissner A, et al. Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis. Bioorg Med Chem. 2013 Nov 1;21(21):6385-97.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₅H₁₀N₄O₃S
• 分子量: 326.330
• 精确质量: 326.047363
• LogP: 2.47
• InChIKey: CENQWLUZEXKRGF-UHFFFAOYSA-N
• SMILES: O=C(Nc1nc(-c2ccccn2)cs1)c1ccccc1[N+](=O)[O-]
• 折射率: 1.710
• 储存条件: 2-8°C， 干燥

靶点实验

查看更多实验

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL730080

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL730079

实验名称：GPR151 activator identification: cell-based high-throughput counter-screen assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Glucose-dependent insulinotropic receptor; AltName: Full=G-protein coupled receptor 119 External Id：GPR119_PHUNTER_AG_LUMI_1536_3X%ACT CSRUN1

实验名称：GPR151 activator identification: cell-based high-throughput confirmation assay 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_3X%ACT CRUN1

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv in Middlebrook 7H9 b... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL2447071

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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英文别名

• 2-Nitro-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]benzamide