Amde-1

• 常用名: Amde-1
• 英文名: Amde-1
• CAS号: 478043-30-0
• 分子量: 415.72
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₈ClF₆N₃
• 熔点: N/A
• 闪点: N/A

Amde-1用途

AMDE-1是一种有效的自噬诱导剂。AMDE-1通过AMPK-mTORC1-ULK1途径诱导自噬,同时通过引起溶酶体功能障碍抑制自噬介导的降解。AMDE-1可用于癌症的研究[1]。

Amde-1名称

• 英文名: AMDE-1

Amde-1生物活性

• 描述: AMDE-1是一种有效的自噬诱导剂。AMDE-1通过AMPK-mTORC1-ULK1途径诱导自噬,同时通过引起溶酶体功能障碍抑制自噬介导的降解。AMDE-1可用于癌症的研究[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
• 参考文献:

  [1]. Li M, et, al. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083.

Amde-1物理化学性质

• 分子式: C₁₈H₈ClF₆N₃
• 分子量: 415.72
• InChIKey: QPWWAOMXYPIDOY-UHFFFAOYSA-N
• SMILES: N#CC(c1cccc(Cl)c1)c1ccc2c(C(F)(F)F)cc(C(F)(F)F)nc2n1

Amde-1靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Confirmed inhibitors of the Cav3 T-type Calcium Channel 来源：1043 靶标：voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] External Id：SAID_463087

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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