3,4,5-trihydroxy-6-methylphthalaldehyde

• 常用名: 3,4,5-trihydroxy-6-methylphthalaldehyde
• 英文名: 3,4,5-trihydroxy-6-methylphthalaldehyde
• CAS号: 483-53-4
• 分子量: 196.15700
• 密度: 1.577g/cm3
• 沸点: 353.7ºC at 760mmHg
• 分子式: C₉H₈O₅
• 熔点: N/A
• 闪点: 181.9ºC

用途

黄素是一种芳香烃受体(Ahr)激动剂,可诱导小鼠CD4+T细胞和CD11b+巨噬细胞表达Ahr下游基因。黄素抑制Arid5a对Il23a 3′UTR的稳定作用,Il23a 3′UTR是一种新发现的靶mRNA[1]。Flavipin具有清除DPPH自由基的能力,IC50值为7.2μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为33.8μM[2]。

3,4,5-trihydroxy-6-methylphthalaldehyde名称

• 英文名: 3,4,5-trihydroxy-6-methylphthalaldehyde

3,4,5-trihydroxy-6-methylphthalaldehyde生物活性

• 描述: 黄素是一种芳香烃受体(Ahr)激动剂,可诱导小鼠CD4+T细胞和CD11b+巨噬细胞表达Ahr下游基因。黄素抑制Arid5a对Il23a 3′UTR的稳定作用,Il23a 3′UTR是一种新发现的靶mRNA[1]。Flavipin具有清除DPPH自由基的能力,IC50值为7.2μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为33.8μM[2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 芳基烃受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. "Alzahrani A, et al. Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis. Saudi Pharm J. 2020;28(12):1605-1615. "

  [2]. Li H, et al. Polyketides from two Chaetomium species and their biological functions. J Antibiot (Tokyo). 2018;71(7):677-681.

3,4,5-trihydroxy-6-methylphthalaldehyde物理化学性质

• 密度: 1.577g/cm3
• 沸点: 353.7ºC at 760mmHg
• 分子式: C₉H₈O₅
• 分子量: 196.15700
• 闪点: 181.9ºC
• 精确质量: 196.03700
• PSA: 94.83000
• LogP: 0.73680
• 蒸汽压: 1.73E-05mmHg at 25°C
• 折射率: 1.741

3,4,5-trihydroxy-6-methylphthalaldehyde靶点实验

查看更多实验

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：USP28 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 28 External Id：USP28 FAST DUB HTS Primary

实验名称：USP10 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 10 External Id：USP10 FAST DUB HTS Primary

实验名称：UCHL1 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin C-terminal hydrolase L1 External Id：UCHL1 FAST DUB HTS Primary

实验名称：OTUD3 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：OTU deubiquitinase 3 External Id：OTUD3 FAST DUB HTS Primary

实验名称：USP30 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 30 External Id：USP30 FAST DUB HTS Primary

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3,4,5-trihydroxy-6-methylphthalaldehyde英文别名

• 1,2-Benzenedicarboxaldehyde,3,4,5-trihydroxy-6-methyl
• 3,4,5-Trihydroxy-6-methyl-1,2-benzenedicarboxaldehyde
• Phthalaldehyde,3,4,5-trihydroxy-6-methyl