NMDA receptor potentiator-1

• 常用名: NMDA receptor potentiator-1
• 英文名: NMDA receptor potentiator-1
• CAS号: 486427-18-3
• 分子量: 467.94
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₆ClNO₅
• 熔点: N/A
• 闪点: N/A

NMDA receptor potentiator-1用途

NMDA受体增强剂-1(化合物1368)是一种亚单位选择性NMDA受体增效剂,针对NR2C和NR2D表达的IC50分别为4μM和5μM[1]。

NMDA receptor potentiator-1名称

• 英文名: NMDA receptor potentiator-1

NMDA receptor potentiator-1生物活性

• 描述: NMDA受体增强剂-1(化合物1368)是一种亚单位选择性NMDA受体增效剂,针对NR2C和NR2D表达的IC50分别为4μM和5μM[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点实验:

  NR2C:4 μM (IC50)

  NR2D:5 μM (IC50)

• 参考文献:

  [1]. Stephen F. Traynelis, et al. Subunit selective NMDA receptor potentiators for the treatment of neurological conditions. Patent US8822462.

NMDA receptor potentiator-1物理化学性质

• 分子式: C₂₆H₂₆ClNO₅
• 分子量: 467.94
• InChIKey: KLJQHLQVCFUHRQ-UHFFFAOYSA-N
• SMILES: COc1ccc(OCC2c3cc(OC)c(OC)cc3CCN2C(=O)c2ccc(Cl)cc2)cc1

NMDA receptor potentiator-1靶点实验

查看更多实验

实验名称：Activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus oocytes assess... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2A External Id：CHEMBL2400431

实验名称：Activity at rat recombinant GluN1/GluN2B receptor expressed in Xenopus oocytes assess... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 1 External Id：CHEMBL2400430

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 1 External Id：CHEMBL2400425

实验名称：Activity at rat recombinant GluN1/GluN2C receptor expressed in Xenopus oocytes assess... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 1 External Id：CHEMBL2400429

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assess... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2D External Id：CHEMBL2400428

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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