长春西汀杂质B

更新时间：2025-08-20 17:23:52

长春西汀杂质B结构式	常用名	长春西汀杂质B	英文名	Apovincamine
	CAS号	4880-92-6	分子量	336.42700
	密度	1.3g/cm3	沸点	405.7ºC at 760mmHg
	分子式	C₂₁H₂₄N₂O₂	熔点	160-162℃
	MSDS	N/A	闪点	199.1ºC

长春西汀杂质B用途

Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。

中文名	阿扑长春胺
英文名	Apovincamine
中文别名	长春西汀杂质B
英文别名	更多

描述	Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
体外研究	载脂蛋白(顺式载脂蛋白胺；6.3、12.5、25、50、100μM)剂量依赖性抑制细胞活性,IC50为49.8μM,并在B16小鼠黑色素瘤细胞中显示抗黑素生成[1]。
参考文献	[1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21.

密度	1.3g/cm3
沸点	405.7ºC at 760mmHg
熔点	160-162℃
分子式	C₂₁H₂₄N₂O₂
分子量	336.42700
闪点	199.1ºC
精确质量	336.18400
PSA	34.47000
LogP	3.69610
InChIKey	OZDNDGXASTWERN-CTNGQTDRSA-N
SMILES	CCC12C=C(C(=O)OC)n3c4c(c5ccccc53)CCN(CCC1)C42
折射率	1.678

长春西汀杂质B毒性英文版

危险品运输编码	NONH for all modes of transport

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CAS号42971-09-5 长春西汀

Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network.

Neurobiol. Aging 11(1) , 39-46, (1990)

Changes in the pericapillary microenvironment of adult (18-month-old) and senescent (27 1/2-month-old) Fischer-344 rats treated for 6 weeks with daily IP injections of brovincamine or apovincamine (0,...

Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.

Bioorg. Med. Chem. 18(12) , 4415-21, (2010)

Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alp...

Synthesis of vinca alkaloids and related compounds. Part 84. Sulfonamide derivatives of some vinca alkaloids with cardiovascular activity.

Arch. Pharm. (Weinheim) 330(6) , 190-8, (1997)

(+)-Vincamine (1) and (+)-vinpocetine (2) were chlorosulfonylated and the resulting sulfonyl chloride isomers (3-6) were transformed into sulfonamides (7-10). The ester group of sulfonamides was modif...