N-[4-氯-3-[5-(二甲基氨基)-1H-苯并咪唑-2-基]苯基]-3,5-二甲氧基苯甲酰胺

• 常用名: N-[4-氯-3-[5-(二甲基氨基)-1H-苯并咪唑-2-基]苯基]-3,5-二甲氧基苯甲酰胺
• 英文名: HhAntag
• CAS号: 496794-70-8
• 分子量: 450.91700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₃ClN₄O₃
• 熔点: N/A
• 闪点: N/A

用途

HhAntag是GLI1介导的转录抑制剂,具有抗肿瘤活性。

名称

• 中文名: N-[4-氯-3-[5-(二甲基氨基)-1H-苯并咪唑-2-基]苯基]-3,5-二甲氧基苯甲酰胺
• 英文名: N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide

生物活性

• 描述: HhAntag是GLI1介导的转录抑制剂,具有抗肿瘤活性。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GLI
  研究领域 >> 癌症
• 参考文献:

  [1]. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30.

  [2]. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811.

  [3]. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410.

物理化学性质

• 分子式: C₂₄H₂₃ClN₄O₃
• 分子量: 450.91700
• 精确质量: 450.14600
• PSA: 82.97000
• LogP: 5.60280
• InChIKey: UBHJFPVTEATUFS-UHFFFAOYSA-N
• SMILES: COc1cc(OC)cc(C(=O)Nc2ccc(Cl)c(-c3nc4ccc(N(C)C)cc4[nH]3)c2)c1
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition ... 来源：ChEMBL 靶标：Smoothened homolog External Id：CHEMBL2161253

实验名称：Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase repo... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL969583

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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英文别名

• CS-1233
• GLI1-mediated tranion inhibitor
• HhAntag