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23-epi-26-Deoxyactein

更新时间:2024-01-14 12:18:04

23-epi-26-Deoxyactein结构式
23-epi-26-Deoxyactein结构式
品牌特惠专场
常用名 23-epi-26-Deoxyactein 英文名 23-epi-26-Deoxyactein
CAS号 501938-01-8 分子量 660.83
密度 N/A 沸点 N/A
分子式 C37H56O10 熔点 N/A
MSDS N/A 闪点 N/A

 23-epi-26-Deoxyactein用途


23-epi-26-Deoxyactein是一种天然的口服活性抗肥胖和抗癌化合物[1][2][3]。

 23-epi-26-Deoxyactein名称

英文名 23-epi-26-Deoxyactein

 23-epi-26-Deoxyactein生物活性

描述 23-epi-26-Deoxyactein是一种天然的口服活性抗肥胖和抗癌化合物[1][2][3]。
相关类别
体外研究 23-epi-26-脱氧核苷元(DA:10μM和20μM)通过下调关键脂肪生成转录因子C/ebpα、C/ebpβ和Pparγ的表达抑制3T3-L1脂肪生成[1]。23-epi-26-脱氧胞苷(DA)促进胰腺β细胞的线粒体生物发生,防止甲基乙二醛诱导的氧化细胞损伤,并保护成骨细胞免受抗霉素A诱导的细胞损伤[2]。23-epi-26-Deoxyactein(DA)抑制MCF7人乳腺癌细胞的生长,并诱导细胞周期停滞在G1期(IC50为21μM)[3]。23-epi-26-Deoxyactein(0.1-1μM)保护成骨细胞免受抗霉素A诱导的细胞损伤[4]。细胞分化试验[1]细胞系:3T3-L1前脂肪细胞。浓度:0-50μM。孵化时间:8天。结果:10μmda主要在分化早期抑制3T3-L1前脂肪细胞的脂肪生成。
体内研究 23-epi-26-Deoxyactein(DA:5和10 mg/kg/d)显著降低HFD喂养小鼠的体重增加、脂肪量和肝脏重量。23-表-26-脱氧胞苷元(DA)还可降低HFD喂养小鼠的胰岛素抵抗和血清脂蛋白水平[1]。23-epi-26-脱氧肌苷元(DA)通过激活AMPK信号和SIRT1-FOXO1途径促进小鼠脂肪细胞的脂解[1]。动物模型:饮食诱导C57BL/6小鼠肥胖[1]。剂量:1-10mg/kg。给药:口服,每日一次,持续12周。结果:降低了体重增加、脂肪质量和肝脏重量。5 mg/kg/d DA显著改善HFD诱导的葡萄糖不耐受。
参考文献

[1]. Jingjing Yuan, et al. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice. Phytomedicine. 2020 Jun 5;76:153264.

[2]. Kwang Sik Suh, et al. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int J Mol Med. 2017 Aug;40(2):539-548.

[3]. Einbond, L.S., et al. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res. Treat. 83, 221–231. Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

[4]. Eun Mi Choi, et al. Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. J Appl Toxicol. 2013 Jun;33(6):488-94.

 23-epi-26-Deoxyactein物理化学性质

分子式 C37H56O10
分子量 660.83
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