23-epi-26-Deoxyactein
Modify Date: 2024-01-14 12:18:04
23-epi-26-Deoxyactein structure
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Common Name | 23-epi-26-Deoxyactein | ||
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| CAS Number | 501938-01-8 | Molecular Weight | 660.83 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H56O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 23-epi-26-Deoxyactein23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound[1][2][3]. |
| Name | 23-epi-26-Deoxyactein |
|---|
| Description | 23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound[1][2][3]. |
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| Related Catalog | |
| In Vitro | 23-epi-26-Deoxyactein (DA :10 μM and 20 μM) inhibits 3T3-L1 adipogenesis through down-regulating the expression of C/ebpα, C/ebpβ, and Pparγ, which are the critical adipogenic transcription factors[1]. 23-epi-26-Deoxyactein (DA) promotes mitochondrial biogenesis in pancreatic β-cells preventing methylglyoxal-induced oxidative cell damage and protects osteoblasts against Antimycin A-induced cell damage[2]. 23-epi-26-Deoxyactein (DA) inhibits growth of the MCF7 human breast cancer cells and induces cell cycle arrest at G1 (IC50 of 21μM)[3]. 23-epi-26-Deoxyactein (0.1-1 μM) protects osteoblasts against Antimycin A-induced cell damage[4]. Cell Differentiation Assay[1] Cell Line: 3T3-L1 preadipocytes. Concentration: 0-50 μM. Incubation Time: 8 days. Result: 10 μM DA inhibited the adipogenesis of 3T3-L1 preadipocytes mainly at the early stage of differentiation. |
| In Vivo | 23-epi-26-Deoxyactein (DA: 5 and 10 mg/kg/d) significantly lowers body weight gain, fat mass, and liver weight in HFD-fed mice. 23-epi-26-Deoxyactein (DA) also reduces insulin resistance and serum lipoprotein levels in HFD-fed mice[1]. 23-epi-26-Deoxyactein (DA) promotes adipocyte lipolysis in mice through activating the AMPK signaling and SIRT1-FOXO1 pathway[1]. Animal Model: Diet induced obesity in C57BL/6 mice[1]. Dosage: 1-10 mg/kg. Administration: Orally, daily for 12 weeks. Result: Lowered body weight gain, fat mass, and liver weight. 5 mg/kg/d DA significantly improved HFD-induced glucose intolerance. |
| References |
| Molecular Formula | C37H56O10 |
|---|---|
| Molecular Weight | 660.83 |
| InChIKey | GCMGJWLOGKSUGX-WUHYQCRDSA-N |
| SMILES | CC(=O)OC1CC23CC24CCC(OC2OCC(O)C(O)C2O)C(C)(C)C4CCC3C2(C)CC3OC4(CC(C)C3C12C)OCC1(C)OC14 |