帽柱木碱

• 常用名: 帽柱木碱
• 英文名: Mitraphylline
• CAS号: 509-80-8
• 分子量: 368.42600
• 密度: 1.33 g/cm3
• 沸点: 555.2ºC
• 分子式: C₂₁H₂₄N₂O₄
• 熔点: 258-267 °C
• 闪点: 289.6ºC

帽柱木碱用途

Mitraphylline 是绒毛钩藤中主要的五环吲哚类生物碱。Mitraphylline 能抑制脂多糖介导的原代人中性粒细胞活化。

帽柱木碱名称

• 中文名: 帽柱叶碱
• 英文名: methyl (1S,4aS,5aS,6R,10aR)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate

帽柱木碱生物活性

• 描述: Mitraphylline 是绒毛钩藤中主要的五环吲哚类生物碱。Mitraphylline 能抑制脂多糖介导的原代人中性粒细胞活化。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23(2):141-8.

帽柱木碱物理化学性质

• 密度: 1.33 g/cm3
• 沸点: 555.2ºC
• 熔点: 258-267 °C
• 分子式: C₂₁H₂₄N₂O₄
• 分子量: 368.42600
• 闪点: 289.6ºC
• 精确质量: 368.17400
• PSA: 67.87000
• LogP: 2.13840
• InChIKey: JMIAZDVHNCCPDM-DAFCLMLCSA-N
• SMILES: COC(=O)C1=COC(C)C2CN3CCC4(C(=O)Nc5ccccc54)C3CC12
• 外观性状: 粉末
• 折射率: 1.635
• 储存条件: 2-8°C，密封，干燥

帽柱木碱靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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帽柱木碱英文别名

• ajmalicine oxindole-B
• HMS2267P09
• Mitraphilline
• EINECS 208-106-0
• rubradinine
• Mitraphylline
• Mitraphyllin