GP 1A

• 常用名: GP 1A
• 英文名: GP 1A
• CAS号: 511532-96-0
• 分子量: 441.353
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₂₂Cl₂N₄O
• 熔点: N/A
• 闪点: N/A

GP 1A用途

GP1a是大麻素受体2(CB2)的有效激动剂。Gp1a有利于皮肤伤口愈合。GP1a抑制炎症和纤维化,同时促进再上皮化[1]。

GP 1A名称

• 英文名: 1-(2,4-dichlorophenyl)-6-methyl-N-(1-piperidinyl)-4H-indeno[1,2-c]pyrazole-3-carboxamide

GP 1A生物活性

• 描述: GP1a是大麻素受体2(CB2)的有效激动剂。Gp1a有利于皮肤伤口愈合。GP1a抑制炎症和纤维化,同时促进再上皮化[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 参考文献:

  [1]. Zhao C, et al. An enzyme-responsive Gp1a-hydrogel for skin wound healing. J Biomater Appl. 2021;36(4):714-721.

GP 1A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₃H₂₂Cl₂N₄O
• 分子量: 441.353
• 精确质量: 440.117065
• LogP: 5.23
• InChIKey: FNOMTMVRTBHRET-UHFFFAOYSA-N
• SMILES: Cc1ccc2c(c1)Cc1c(C(=O)NN3CCCCC3)nn(-c3ccc(Cl)cc3Cl)c1-2
• 折射率: 1.711

GP 1A靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Selectivity ratio of Ki for CB1 receptor (unknown origin) to Ki for CB2 receptor (unk... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3293296

实验名称：Binding affinity to CB2 receptor (unknown origin) 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL3239857

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Binding affinity to CB1 receptor (unknown origin) 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3239858

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

共27条，当前第1页，共3页

1

2

3

GP 1A英文别名

• 1-(2,4-Dichlorophenyl)-6-methyl-N-(1-piperidinyl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
• 1-(2,4-dichlorophenyl)-6-methyl-N-(1-piperidinyl)-4H-indeno[1,2-c]pyrazole-3-carboxamide
• 1-(2,4-Dichlorophenyl)-6-methyl-N-(piperidin-1-yl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide