竹节参皂苷IVa

• 常用名: 竹节参皂苷IVa
• 英文名: Chikusetsusaponin IVa
• CAS号: 51415-02-2
• 分子量: 794.965
• 密度: 1.4±0.1 g/cm3
• 沸点: 873.3±65.0 °C at 760 mmHg
• 分子式: C₄₂H₆₆O₁₄
• 熔点: 218-220 ºC (methanol , water )
• 闪点: 255.6±27.8 °C

竹节参皂苷IVa用途

竹节参皂苷ⅣA (Chikusetsusaponin IVa) 是三萜皂苷中主要的活性成,是蛋白激酶的激活剂,对血栓及一些代谢性疾病具有抵抗作用。

竹节参皂苷IVa名称

• 中文名: 竹节人参皂苷 Iva
• 英文名: chikusetsusaponin-IVa
• 中文别名: 地肤子皂苷Iib | 竹节参皂苷 Ⅳ | 竹节参皂苷IVa

竹节参皂苷IVa生物活性

• 描述: 竹节参皂苷ⅣA (Chikusetsusaponin IVa) 是三萜皂苷中主要的活性成,是蛋白激酶的激活剂,对血栓及一些代谢性疾病具有抵抗作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 其他
• 参考文献:

  [1]. Wang H, et al.Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells. Int J Immunopathol Pharmacol. 2015 Jul 8.

  [2]. Cui J, et al. Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells. J Ethnopharmacol. 2015 Apr 22;164:334-9.

  [3]. Li Y, et al. Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects. J Pharm Pharmacol. 2015 Jul;67(7):997-1007.

  [4]. Dahmer T, et al. Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté). J Med Food. 2012 Dec;15(12):1073-80.

竹节参皂苷IVa物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 873.3±65.0 °C at 760 mmHg
• 熔点: 218-220 ºC (methanol , water )
• 分子式: C₄₂H₆₆O₁₄
• 分子量: 794.965
• 闪点: 255.6±27.8 °C
• 精确质量: 794.445251
• PSA: 232.90000
• LogP: 6.37
• InChIKey: YOSRLTNUOCHBEA-SGVKAIFKSA-N
• SMILES: CC1(C)CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(O)C6O)C(C)(C)C5CCC43C)C2C1
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.611

竹节参皂苷IVa安全信息

• 安全声明 (欧洲): 24/25

竹节参皂苷IVa靶点实验

查看更多实验

实验名称：Cytotoxicity against human A549 cells assessed as growth inhibition after 3 days by s... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1776274

实验名称：Cytotoxicity against human HL60 cells at 25 uM after 48 hrs by WST8 assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL1111933

实验名称：Cytotoxicity against human DU145 cells assessed as growth inhibition after 3 days by ... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL1776273

实验名称：Cytotoxicity against human PC3 cells at 25 uM after 48 hrs by WST8 assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL1111931

实验名称：Cytotoxicity against human HCT8 cells assessed as growth inhibition after 3 days by s... 来源：ChEMBL 靶标：HCT-8 External Id：CHEMBL1776275

实验名称：Cytotoxicity against human A549 cells at 25 uM after 48 hrs by WST8 assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL1111929

实验名称：Cytotoxicity against human HL60 cells by MTT assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL1293121

实验名称：Inhibition of fMLP/CB-stimulated superoxide anion generation in human neutrophils 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL1776267

实验名称：Cytotoxicity against human MRC5 cells at 25 uM after 48 hrs by WST8 assay 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL1111937

实验名称：Inhibition of fMLP/CB-activated human neutrophil degranulation assessed as inhibition... 来源：ChEMBL 靶标：Neutrophil External Id：CHEMBL1776269

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竹节参皂苷IVa英文别名

• Chikusetsusaponin
• Chikusetsusaponin Iva
• 1-O-[(3α,5ξ,9ξ)-3-(β-D-Glucopyranuronosyloxy)-28-oxoolean-12-en-28-yl]-β-D-glucopyranose
• GLUCOPYRANOSIDURONIC ACID
• Silphioside G
• Chikusetsu saponin Ⅳa
• Chikusetsu Saponin IVa
• 1-O-[(3β)-3-(β-D-Glucopyranuronosyloxy)-28-oxoolean-12-en-28-yl]-β-D-glucopyranose
• Calenduloside F
• Chikusetsusaponin IV