新海胆灵A

• 常用名: 新海胆灵A
• 英文名: Neoechinulin A
• CAS号: 51551-29-2
• 分子量: 323.389
• 密度: 1.2±0.1 g/cm3
• 沸点: 655.7±55.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁N₃O₂
• 熔点: N/A
• 闪点: 350.4±31.5 °C

新海胆灵A用途

新棘菊素A是一种异戊烯基吲哚生物碱,具有清除、神经营养因子样和抗凋亡活性。新棘菊素A诱导小鼠记忆改善和抗抑郁样作用[1][2]。

新海胆灵A名称

• 中文名: 新海胆灵 A
• 英文名: (3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]meth ylene}-2,5-piperazinedione

新海胆灵A生物活性

• 描述: 新棘菊素A是一种异戊烯基吲哚生物碱,具有清除、神经营养因子样和抗凋亡活性。新棘菊素A诱导小鼠记忆改善和抗抑郁样作用[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 神经疾病
• 体外研究: 新菊粉A(RAW264.7巨噬细胞；3小时；然后用LPS(1μg/mL)刺激细胞18小时)以剂量依赖性方式抑制PGE2、TNF-α和IL-1β的产生[2]。新菊粉A可抑制促炎介质和细胞因子的产生,包括NO、PGE2、TNF-α和IL-1β。此外,它通过抑制NF-κB和p38 MAPK信号通路降低LPS刺激的RAW264.7巨噬细胞中iNOS和COX-2的表达[2]。新菊粉A抑制淀粉样β低聚物诱导的小胶质细胞激活,从而保护PC-12细胞免受炎症介导的毒性[3]。
• 体内研究: 在Y-迷宫试验中,侧脑室注射LPS(10μg/只小鼠)显著降低了自发交替行为,这是由先前注射新菊粉A(300ng/只小鼠,i.c.v.)阻止的[1]。
• 参考文献:

  [1]. Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4.

  [2]. Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Published 2013 Oct 25.

  [3]. Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40.

新海胆灵A物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 655.7±55.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁N₃O₂
• 分子量: 323.389
• 闪点: 350.4±31.5 °C
• 精确质量: 323.163391
• PSA: 73.99000
• LogP: 2.55
• InChIKey: MYRPIYZIAHOECW-GDNBJRDFSA-N
• SMILES: C=CC(C)(C)c1[nH]c2ccccc2c1C=C1NC(=O)C(C)NC1=O
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.628
• 储存条件: 2-8℃，干燥，密闭

新海胆灵A安全信息

• 危害码 (欧洲): Xi

新海胆灵A靶点实验

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实验名称：Cytotoxicity against human BXPC3 cells assessed as concentration required for 50% inh... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL925905

实验名称：Cytotoxicity against mouse P388 cells assessed as concentration required for 50% inhi... 来源：ChEMBL 靶标：P388 External Id：CHEMBL925899

实验名称：Cytotoxicity against human OVCAR-3 cells assessed as concentration required for 50% i... 来源：ChEMBL 靶标：OVCAR-3 External Id：CHEMBL925900

实验名称：DPPH radical scavenging activity 来源：ChEMBL 靶标：N/A External Id：CHEMBL925688

实验名称：Cytotoxicity against human SF295 cells assessed as concentration required for 50% inh... 来源：ChEMBL 靶标：SF-295 External Id：CHEMBL925908

实验名称：Cytotoxicity against human DU145 cells assessed as concentration required for 50% inh... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL925909

实验名称：Inhibition of influenza A virus A/WSN/33 (H1N1) Hemagglutinin 1 binding to sialic aci... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3418867

实验名称：Inhibition of influenza A virus A/WSN/33 (H1N1) Hemagglutinin 1 binding to sialic aci... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3418868

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新海胆灵A英文别名

• (3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]methylene}-2,5-piperazinedione
• (3S,6Z)-3-methyl-6-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methylidene}piperazine-2,5-dione